SCHEMBL5690784

SCHEMBL5690784

O=C(Oc1ccc(Cc2ccccn2)cc1)N1CCC(On2ccnc2)CC1

nearest known ligand 0.46

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FAAH O00519 2/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
ALDH1A1 P00352 5/20 0.38
GAA P10253 1/20 0.38
NPY2R P49146 1/20 0.37
CYP3A4 P08684 4/20 0.37
CYP2C9 P11712 3/20 0.37
TSHR P16473 2/20 0.37
HSD17B10 Q99714 2/20 0.37
MAPK1 P28482 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
CYP1A2 P05177 2/20 0.37
CYP2C19 P33261 1/20 0.37
MGLL Q99685 1/20 0.37
LIPE Q05469 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5689356 0.87 GRIN2B (0.39) NPC1RAB9AGAANPY2RSMN1; SMN2
SCHEMBL5690492 0.86 KMT2A (0.40) FAAHNPC1RAB9AALDH1A1GAA
SCHEMBL5690427 0.86 NOS1 (0.39) FAAHGAANPY2RCYP2C9CYP1A2
SCHEMBL5690515 0.85 RAB9A (0.42) NPC1RAB9AALDH1A1GAANPY2R
SCHEMBL5688744 0.84 GRIN2B (0.38) FAAHNPC1RAB9AALDH1A1GAA
SCHEMBL5689036 0.84 SMO (0.38) FAAHNPC1RAB9AGAANPY2R
SCHEMBL5689401 0.84 LIPE (0.49) SMN1; SMN2LIPE
SCHEMBL5689569 0.84 FAAH (0.39) FAAHNPC1RAB9AALDH1A1GAA
SCHEMBL5689128 0.82 FAAH (0.37) FAAHNPC1RAB9AGAANPY2R
SCHEMBL5689513 0.82 LIPE (0.45) FAAHLIPE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US claimed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP claimed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO claimed
US-20060160851-A1 Substituted piperidine carbamates NOVO NORDISK A/S (DK) 2006-07-20 US disclosed
EP-1636207-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2006-03-22 EP disclosed
WO-2004111032-A1 SUBSTITUTED PIPERIDINE CARBAMATES FOR USE AS INHIBITORS OF HORMONE SENSITIVE LIPASE NOVO NORDISK A/S (DK) 2004-12-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060160851-A1 Substituted piperidine carbamates LIPE, PNLIP, LIPC FAAH 160/4885NPC1 601/4885RAB9A 1253/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.