Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.54 |
| ▸ | GUSB | P08236 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KIF11 | P52732 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29357488 | 1.00 | DHFR (0.54) | DHFRGUSBGAAKIF11ALDH1A1 | |
| SCHEMBL5696249 | 0.85 | DHFR (0.51) | DHFRGUSBKIF11ALDH1A1HTT | |
| SCHEMBL5176445 | 0.85 | DHFR (0.51) | DHFRGUSBKIF11ALDH1A1LMNA | |
| SCHEMBL5696173 | 0.83 | DHFR (0.50) | DHFRGUSBKIF11ALDH1A1MEN1 | |
| SCHEMBL5696188 | 0.83 | DHFR (0.50) | DHFRGUSBGAAKIF11LMNA | |
| SCHEMBL29857451 | 0.83 | DHFR (0.50) | DHFRGUSBGAAKIF11LMNA | |
| SCHEMBL9567855 | 0.82 | ALDH1A1 (0.54) | DHFRGUSBGAAALDH1A1LMNA | |
| SCHEMBL5176626 | 0.82 | ALDH1A1 (0.54) | DHFRGUSBGAAALDH1A1LMNA | |
| SCHEMBL5696167 | 0.79 | DHFR (0.57) | DHFRGUSBKIF11ALDH1A1LMNA | |
| SCHEMBL9701173 | 0.77 | DHFR (0.62) | DHFRGUSBGAAKIF11ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655289-A1 | Quinazoline derivatives, process for their preparation, their use as antimitotics and pharmaceutical compositions comprising said derivatives | EMBL (DE) | 2006-05-10 | — | — | EP | disclosed |