Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.36 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696249 | 0.91 | DHFR (0.51) | DHFRGUSBHTR2AHTR2CTSHR | |
| SCHEMBL5205016 | 0.85 | ALDH1A1 (0.46) | TSHRATMMEN1KMT2ATRPM4 | |
| SCHEMBL5696188 | 0.84 | DHFR (0.50) | DHFRGUSBMEN1KMT2AKIF11 | |
| SCHEMBL29857451 | 0.84 | DHFR (0.50) | DHFRGUSBMEN1KMT2AKIF11 | |
| SCHEMBL5696233 | 0.83 | DHFR (0.54) | DHFRGUSBMEN1KMT2AKIF11 | |
| SCHEMBL29357488 | 0.83 | DHFR (0.54) | DHFRGUSBMEN1KMT2AKIF11 | |
| SCHEMBL5176445 | 0.77 | DHFR (0.51) | DHFRGUSBHTR2AHTR2CKIF11 | |
| SCHEMBL5177579 | 0.76 | ALDH1A1 (0.46) | DHFRGUSBHTR2AHTR2CMEN1 | |
| SCHEMBL5177430 | 0.75 | MAPT (0.50) | HTR2AHTR2CTSHRATMMEN1 | |
| SCHEMBL5696272 | 0.73 | CHRM1 (0.42) | HTR2AHTR2CTSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655289-A1 | Quinazoline derivatives, process for their preparation, their use as antimitotics and pharmaceutical compositions comprising said derivatives | EMBL (DE) | 2006-05-10 | — | — | EP | disclosed |