Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696173 | 0.91 | DHFR (0.50) | DHFRGUSBHTR2AHTR2CTSHR | |
| SCHEMBL5177579 | 0.86 | ALDH1A1 (0.46) | DHFRGUSBHTR2AHTR2CKIF11 | |
| SCHEMBL5696233 | 0.85 | DHFR (0.54) | DHFRGUSBKIF11ALDH1A1HTT | |
| SCHEMBL29357488 | 0.85 | DHFR (0.54) | DHFRGUSBKIF11ALDH1A1HTT | |
| SCHEMBL5176445 | 0.84 | DHFR (0.51) | DHFRGUSBHTR2AHTR2CKIF11 | |
| SCHEMBL5696188 | 0.77 | DHFR (0.50) | DHFRGUSBKIF11 | |
| SCHEMBL29857451 | 0.77 | DHFR (0.50) | DHFRGUSBKIF11 | |
| SCHEMBL5205016 | 0.74 | ALDH1A1 (0.46) | TSHRKIF11ALDH1A1 | |
| SCHEMBL9701173 | 0.74 | DHFR (0.62) | DHFRGUSBKIF11ALDH1A1SMN1; SMN2 | |
| SCHEMBL5696167 | 0.73 | DHFR (0.57) | DHFRGUSBKIF11ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655289-A1 | Quinazoline derivatives, process for their preparation, their use as antimitotics and pharmaceutical compositions comprising said derivatives | EMBL (DE) | 2006-05-10 | — | — | EP | disclosed |