Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.69 |
| ▸ | HTR5A | P47898 | 2/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.69 |
| ▸ | HTR2A | P28223 | 2/20 | 0.69 |
| ▸ | HTR7 | P34969 | 2/20 | 0.69 |
| ▸ | HTR3A | P46098 | 2/20 | 0.69 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.69 |
| ▸ | HTR3B | O95264 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | NCF1 | P14598 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
| ▸ | HTR1D | P28221 | 1/20 | 0.69 |
| ▸ | HTR1B | P28222 | 1/20 | 0.69 |
| ▸ | MTOR | P42345 | 1/20 | 0.69 |
| ▸ | HTR6 | P50406 | 1/20 | 0.69 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.69 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1876619 | 0.96 | NCF1 (0.69) | HTR1AHTR5AHSD17B10HTR2AHTR7 | |
| SCHEMBL3080094 | 0.94 | NCF1 (0.67) | HTR1AHTR5AHSD17B10HTR2AHTR7 | |
| SCHEMBL7491687 | 0.94 | NCF1 (0.67) | HTR1AHTR5AHSD17B10HTR2AHTR7 | |
| Lithium SCHEMBL31260768 | 0.94 | NCF1 (0.67) | HTR1AHTR5AHSD17B10HTR2AHTR7 | |
| SCHEMBL9643856 | 0.91 | HTR1A (0.74) | HTR1AHTR5AHSD17B10HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL7203515 | 0.89 | KDM4E (0.75) | HTR1AHTR5AHSD17B10HTR2AHTR7 | |
| SCHEMBL29081094 | 0.88 | CYP1A2 (0.56) | HTR1AHTR5AHSD17B10HTR2AHTR7 | |
| SCHEMBL17144774 | 0.88 | NCF1 (0.56) | HTR1AHTR5AHSD17B10HTR2AHTR7 | |
| SCHEMBL20887135 | 0.84 | NCF1 (0.56) | HTR1AHTR5AHSD17B10HTR2AHTR7 | |
| SCHEMBL7719591 | 0.84 | HTR6 (0.87) | HTR1AHTR5AHSD17B10HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2601190-B1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2018-07-04 | — | — | EP | disclosed |
| CN-104169273-B | Dihydrofuran azetidine derivatives as antiparasitic | 硕腾服务有限责任公司 | 2016-11-02 | — | — | CN | disclosed |
| CN-104271568-B | As the azetidine derivatives of antiparasitic | ZOETIS SERVICES LLC (US) | 2016-05-04 | — | — | CN | disclosed |
| EP-2814825-B1 | DIHYDROFURAN AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2016-03-23 | — | — | EP | disclosed |
| CN-103270036-B | As antiparasitic isoxazoline derivative | ZOETIS LLC (US) | 2015-11-25 | — | — | CN | disclosed |
| US-9133172-B2 | Dihydrofuran azetidine derivatives as antiparasitic agents | ZOETIS SERVICES LLC (US) | 2015-09-15 | — | — | US | disclosed |
| US-9073912-B2 | Azetidine derivatives as antiparasitic agents | ZOETIS SERVICES LLC (US) | 2015-07-07 | — | — | US | disclosed |
| US-20150119377-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2015-04-30 | — | — | US | disclosed |
| EP-2855457-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | Zoetis Products LLC (US) | 2015-04-08 | — | — | EP | disclosed |
| US-20150038440-A1 | DIHYDROFURAN AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2015-02-05 | — | — | US | disclosed |
| CN-104271568-A | Azetidine derivatives as antiparasitic agents | ZOETIS LLC | 2015-01-07 | — | — | CN | disclosed |
| EP-2814825-A1 | DIHYDROFURAN AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | Zoetis LLC (US) | 2014-12-24 | — | — | EP | disclosed |
| CN-104169273-A | Dihydrofuran azetidine derivatives as antiparasitic agents | ZOETIS LLC | 2014-11-26 | — | — | CN | disclosed |
| WO-2013169622-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS LLC (US) | 2013-11-14 | — | — | WO | disclosed |
| CN-103270036-A | Isoxazoline derivatives as antiparasitic agents | PFIZER | 2013-08-28 | — | — | CN | disclosed |
| WO-2013116230-A1 | DIHYDROFURAN AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS LLC (US) | 2013-08-08 | — | — | WO | disclosed |
| EP-2601190-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | AH USA 42 LLC (US) | 2013-06-12 | — | — | EP | disclosed |
| US-8415310-B2 | Isoxazoline derivatives as antiparasitic agents | AH USA 42 LLC (US) | 2013-04-09 | — | — | US | disclosed |
| US-20120035122-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC | 2012-02-09 | — | — | US | disclosed |
| WO-2012017359-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | PFIZER INC. (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038440-A1 | DIHYDROFURAN AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | QDPR, DHFR, DHODH | HTR1A 155/4885HTR5A 525/4885HSD17B10 3775/4885 |
| US-20120035122-A1 | ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS | ADORA1, CYP3A7, RDX | HTR1A 215/4885HTR5A 729/4885HSD17B10 3995/4885 |
| US-20150119377-A1 | AZETIDINE DERIVATIVES AS ANTIPARASITIC AGENTS | CYP1B1, ADORA1, QDPR | HTR1A 328/4885HTR5A 840/4885HSD17B10 4181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.