Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.53 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5697234 | 0.92 | HDAC8 (0.48) | PTGER4PTGER2LMNAMAPTTP53 | |
| SCHEMBL5697224 | 0.88 | NR4A2 (0.45) | PTGER4PTGER2LMNATP53POLB | |
| SCHEMBL5697068 | 0.84 | NTSR1 (0.52) | PTGER4PTGER2LMNAMAPTTP53 | |
| SCHEMBL5697002 | 0.84 | MMP13 (0.62) | LMNATP53POLBMMP13HDAC8 | |
| SCHEMBL5697056 | 0.84 | KMT2A (0.43) | LMNAMAPTTP53MMP13ALDH1A1 | |
| SCHEMBL5922902 | 0.79 | MMP13 (0.55) | MAPTTP53MMP13HDAC8HDAC1 | |
| SCHEMBL5697139 | 0.76 | HDAC6 (0.53) | LMNAMAPTMMP13ALDH1A1HDAC8 | |
| SCHEMBL2611251 | 0.76 | HDAC8 (0.58) | PTGER4PTGER2LMNAMAPTTP53 | |
| SCHEMBL8340351 | 0.76 | EGLN1 (0.46) | PTGER4PTGER2LMNAPOLBMMP13 | |
| SCHEMBL5696910 | 0.75 | MMP13 (0.69) | MMP13HDAC8HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060247231-A1 | Amide and ester matrix metalloproteinase inhibitors | WARNER-LAMBERT COMPANY LLC | 2006-11-02 | — | — | US | disclosed |
| EP-1680125-A1 | COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A LIGAND TO AN ALPHA-2-DELTA RECEPTOR | Warner-Lambert Company LLC (US) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005002585-A1 | COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 AND A LIGAND TO AN ALPHA-2-DELTA RECEPTOR | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-13 | — | — | WO | disclosed |
| US-20050004177-A1 | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor | WARNER-LAMBERT COMPANY LLC | 2005-01-06 | — | — | US | disclosed |
| US-20040142950-A1 | Amide and ester matrix metalloproteinase inhibitors | BUNKER AMY MAE (US) | 2004-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247231-A1 | Amide and ester matrix metalloproteinase inhibitors | MMP13, MMP9, MMP3 | PTGER4 714/4885PTGER2 546/4885LMNA 2778/4885 |
| US-20050004177-A1 | Combination of an allosteric inhibitor of matrix metalloproteinase-13 and a ligand to an alpha-2-delta receptor | MMP13, MMP10, MMP11 | PTGER4 1026/4885PTGER2 157/4885LMNA 2011/4885 |
| US-20040142950-A1 | Amide and ester matrix metalloproteinase inhibitors | MMP13, MMP11, MMP9 | PTGER4 482/4885PTGER2 242/4885LMNA 2819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.