SCHEMBL5708298

SCHEMBL5708298

O=C(O)Cc1cc(Cl)c(NC(=O)c2c[nH]c3c(F)cccc23)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.42
GUSB P08236 4/20 0.41
NHERF1 O14745 1/20 0.41
HAT1 O14929 2/20 0.40
EP300 Q09472 2/20 0.40
SUCNR1 Q9BXA5 1/20 0.39
PTGS2 P35354 2/20 0.39
ABCB11 O95342 1/20 0.39
PTGS1 P23219 1/20 0.39
PPARG P37231 1/20 0.39
NR1I3 Q14994 1/20 0.39
MPO P05164 3/20 0.39
HDAC3 O15379 1/20 0.39
HDAC1 Q13547 1/20 0.39
NR4A2 P43354 1/20 0.38
GPR84 Q9NQS5 1/20 0.38
PCSK9 Q8NBP7 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5708329 0.86 PKM (0.40) GUSBNHERF1HAT1EP300NR4A2
SCHEMBL14591887 0.83 HAT1 (0.41) RAB9AGUSBNHERF1HAT1EP300
SCHEMBL72972 0.83 NHERF1 (0.54) NHERF1HAT1EP300
SCHEMBL73753 0.80 NHERF1 (0.51) NHERF1HAT1EP300
SCHEMBL5066540 0.73 GPR84 (0.65) RAB9AMPOGPR84PCSK9
SCHEMBL14626738 0.72 PCSK9 (0.41) RAB9AGUSBNHERF1MPOHDAC3
SCHEMBL14591876 0.72 PCSK9 (0.39) RAB9AGUSBNHERF1HAT1EP300
SCHEMBL71893 0.72 HDAC3 (0.48) RAB9AHDAC3HDAC1
SCHEMBL72182 0.72 MAOB (0.53) RAB9A
SCHEMBL71040 0.70 ITGB1 (0.57) HDAC1NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070149606-A1 Process for producing phenylacetic acid derivative DAIICHI PHARMACEUTICAL CO.,LTD. (JP) 2007-06-28 US disclosed
US-20070149606-A1 Process for producing phenylacetic acid derivative DAIICHI PHARMACEUTICAL CO.,LTD. (JP) 2007-06-28 US disclosed
EP-1698611-A1 PROCESS FOR PRODUCING PHENYLACETIC ACID DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-09-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149606-A1 Process for producing phenylacetic acid derivative UGT1A4, VPS4B, CYP3A4 RAB9A 3214/4885GUSB 506/4885NHERF1 4412/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.