SCHEMBL5708329

SCHEMBL5708329

CCOC(=O)Cc1cc(Cl)c(NC(=O)c2c[nH]c3c(F)cccc23)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.40
POLB P06746 1/20 0.40
GUSB P08236 9/20 0.40
NR4A2 P43354 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.38
HAT1 O14929 1/20 0.38
EP300 Q09472 1/20 0.38
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
KMT2A Q03164 1/20 0.37
NHERF1 O14745 1/20 0.37
CLEC4M Q9H2X3 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5708298 0.86 RAB9A (0.42) GUSBNR4A2HAT1EP300NHERF1
SCHEMBL71626 0.85 PKM (0.57) PKMKDM4EALDH1A1KMT2ANHERF1
SCHEMBL72295 0.82 PKM (0.54) PKMKDM4EALDH1A1KMT2ANHERF1
SCHEMBL14591887 0.80 HAT1 (0.41) POLBGUSBNR4A2HAT1EP300
SCHEMBL73880 0.75 MAOB (0.47)
SCHEMBL5708317 0.75 SMN1; SMN2 (0.43) POLBKDM4EALDH1A1KMT2A
SCHEMBL3579447 0.74 ITGB1 (0.56) NR4A2L3MBTL1ALDH1A1KMT2A
SCHEMBL72819 0.73 MAOB (0.45)
SCHEMBL72217 0.73 MAPT (0.41) L3MBTL1ALDH1A1KMT2A
SCHEMBL14254463 0.73 ITGB1 (0.70)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070149606-A1 Process for producing phenylacetic acid derivative DAIICHI PHARMACEUTICAL CO.,LTD. (JP) 2007-06-28 US disclosed
US-20070149606-A1 Process for producing phenylacetic acid derivative DAIICHI PHARMACEUTICAL CO.,LTD. (JP) 2007-06-28 US disclosed
EP-1698611-A1 PROCESS FOR PRODUCING PHENYLACETIC ACID DERIVATIVE DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2006-09-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149606-A1 Process for producing phenylacetic acid derivative UGT1A4, VPS4B, CYP3A4 PKM 557/4885POLB 1933/4885GUSB 506/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.