SCHEMBL57091

SCHEMBL57091

NC(C(=O)O)c1cccc(C(=O)c2ccc(Br)cc2)c1.[NaH]

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.52
KMT2A Q03164 2/20 0.52
PTGS1 P23219 3/20 0.51
PTGS2 P35354 3/20 0.51
MAPT P10636 3/20 0.51
CXCR1 P25024 2/20 0.51
CXCR2 P25025 2/20 0.51
SMN1; SMN2 Q16637 2/20 0.51
HSD17B10 Q99714 2/20 0.51
RECQL P46063 1/20 0.51
KDM4E B2RXH2 1/20 0.51
ALDH1A1 P00352 1/20 0.51
LMNA P02545 1/20 0.51
CYP3A4 P08684 1/20 0.51
HPGD P15428 1/20 0.51
MAPK1 P28482 1/20 0.51
PMP22 Q01453 1/20 0.51
SLC22A6 Q4U2R8 1/20 0.51
CXCL8 P10145 1/20 0.51
THPO P40225 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL55801 0.98 MEN1 (0.54) MEN1KMT2APTGS1PTGS2MAPT
SCHEMBL11730195 0.89 ALDH1A1 (0.63) MEN1KMT2APTGS1PTGS2MAPT
SCHEMBL512447 0.88 PTGS1 (0.65) MEN1KMT2APTGS1PTGS2MAPT
SCHEMBL7531909 0.87 MEN1 (0.57) MEN1KMT2APTGS1PTGS2MAPT
SCHEMBL11727137 0.86 ALDH1A1 (0.63) MEN1KMT2APTGS1PTGS2MAPT
SCHEMBL11726351 0.86 ALDH1A1 (0.63) MEN1KMT2APTGS1PTGS2MAPT
Methane SCHEMBL11460137 0.86 ALDH1A1 (0.63) MEN1KMT2APTGS1PTGS2MAPT
Water SCHEMBL11467024 0.84 ALDH1A1 (0.61) MEN1KMT2APTGS1PTGS2MAPT
Water SCHEMBL11460877 0.84 ALDH1A1 (0.61) MEN1KMT2APTGS1PTGS2MAPT
SCHEMBL56645 0.84 MEN1 (0.48) MEN1KMT2APTGS1PTGS2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9561277-B2 Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid SENJU PHARMACEUTICAL CO., LTD. (JP) 2017-02-07 US claimed
WO-2015170177-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID SENJU PHARMACEUTICAL CO., LTD. (JP) 2015-11-12 WO claimed
US-9144609-B2 Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid SENJU PHARMACEUTICAL CO., LTD. (JP) 2015-09-29 US claimed
US-20150025149-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID SENJU PHARMACEUTICAL CO., LTD. (JP) 2015-01-22 US claimed
US-20150011634-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID SENJU PHARMACEUTICAL CO., LTD. (JP) 2015-01-08 US claimed
US-8927606-B1 Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid SENJU PHARMACEUTICAL CO., LTD. (JP) 2015-01-06 US claimed
US-8871813-B2 Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid SENJU PHARMACEUTICAL CO., LTD. (JP) 2014-10-28 US claimed
US-20140243413-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID SENJU PHARMACEUTICAL CO., LTD. (JP) 2014-08-28 US claimed
US-20140235721-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID SENJU PHARMACEUTICAL CO., LTD. (JP) 2014-08-21 US claimed
US-8754131-B2 Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid SENJU PHARMACEUTICAL CO., LTD. (JP) 2014-06-17 US claimed
US-20140142183-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID SENJU PHARMACEUTICAL CO., LTD. (JP) 2014-05-22 US claimed
US-8669290-B2 Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid SENJU PHARMACEUTICAL CO., LTD. (JP) 2014-03-11 US claimed
US-8497304-B2 Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid SENJU PHARMACEUTICAL CO., LTD. (JP) 2013-07-30 US claimed
US-20130090384-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID SENJU PHARMACEUTICAL CO., LTD. (JP) 2013-04-11 US claimed
US-20120115957-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID SENJU PHARMACEUTICAL CO., LTD. (JP) 2012-05-10 US claimed
US-8129431-B2 Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid SENJU PHARMACEUTICAL CO., LTD. (JP) 2012-03-06 US claimed
CN-109608351-B Preparation method of bromfenac sodium 合肥久诺医药科技有限公司 2021-06-01 CN disclosed
EP-2653159-B1 BROMFENAC ORGANIC SALTS AND PREPARATION METHOD, COMPOSITION AND USE THEREOF SHENYANG XINGQI PHARMACEUTICAL CO LTD (CN) 2016-06-29 EP disclosed
US-20140039056-A1 BROMFENAC ORGANIC SALTS AND PREPARATION METHOD, COMPOSITION AND USE THEREOF SHENYANG XINGQI PHARMACEUTICAL CO., LTD. (CN) 2014-02-06 US disclosed
EP-2653159-A1 BROMFENAC ORGANIC SALTS AND PREPARATION METHOD, COMPOSITION AND USE THEREOF Shenyang Xingqi Pharmaceutical Co., Ltd. (CN) 2013-10-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140243413-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID AADAT, TLR2, FFAR2 MEN1 4823/4885KMT2A 629/4885PTGS1 132/4885
US-20140142183-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID PAOX, FFAR2, FFAR3 MEN1 4831/4885KMT2A 1176/4885PTGS1 149/4885
US-20130090384-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID PAOX, FFAR2, FFAR3 MEN1 4831/4885KMT2A 1176/4885PTGS1 149/4885
US-20140235721-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID PAOX, FFAR2, FFAR3 MEN1 4831/4885KMT2A 1176/4885PTGS1 149/4885
US-20150025149-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID PAOX, FFAR2, FFAR3 MEN1 4831/4885KMT2A 1176/4885PTGS1 149/4885
US-20150011634-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID PAOX, FFAR2, FFAR3 MEN1 4831/4885KMT2A 1176/4885PTGS1 149/4885
US-20140039056-A1 BROMFENAC ORGANIC SALTS AND PREPARATION METHOD, COMPOSITION AND USE THEREOF ALB, OGFR, BBC3 MEN1 4813/4885KMT2A 3044/4885PTGS1 114/4885
US-20120115957-A1 AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID PAOX, FFAR2, FFAR3 MEN1 4831/4885KMT2A 1176/4885PTGS1 149/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.