Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.43 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.43 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.42 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL57566 | 0.99 | MEN1 (0.47) | MEN1KMT2APTGS1PTGS2MAPT | |
| SCHEMBL11471719 | 0.88 | PTGS1 (0.55) | MEN1KMT2APTGS1PTGS2MAPT | |
| Water SCHEMBL10824628 | 0.87 | PTGS1 (0.54) | MEN1KMT2APTGS1PTGS2MAPT | |
| Water SCHEMBL11467419 | 0.87 | PTGS1 (0.54) | MEN1KMT2APTGS1PTGS2MAPT | |
| SCHEMBL11459880 | 0.86 | PTGS1 (0.43) | PTGS1PTGS2MAPTCXCR1CXCR2 | |
| Methane SCHEMBL11468969 | 0.85 | PTGS1 (0.53) | MEN1KMT2APTGS1PTGS2MAPT | |
| SCHEMBL7531909 | 0.85 | MEN1 (0.57) | MEN1KMT2APTGS1PTGS2MAPT | |
| SCHEMBL55801 | 0.85 | MEN1 (0.54) | MEN1KMT2APTGS1PTGS2MAPT | |
| Potassium Ion SCHEMBL11730580 | 0.85 | PTGS1 (0.55) | MEN1KMT2APTGS1PTGS2MAPT | |
| Water SCHEMBL11470792 | 0.84 | SMN1; SMN2 (0.46) | PTGS1PTGS2MAPTCXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108569975-B | Preparation method of bromfenac sodium sesquihydrate | 扬子江药业集团有限公司 | 2021-01-12 | — | — | CN | claimed |
| CN-113698308-B | Synthesis method of bromfenac sodium | 山东辰龙药业有限公司 | 2024-06-21 | — | — | CN | disclosed |
| CN-112239412-B | Refining and preparation method of bromfenac sodium sesquihydrate | 上海天慈中商药业有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-117647609-A | Method for detecting residual solvent of bromfenac sodium | 辰欣药业股份有限公司 | 2024-03-05 | — | — | CN | disclosed |
| CN-109608351-B | Preparation method of bromfenac sodium | 合肥久诺医药科技有限公司 | 2021-06-01 | — | — | CN | disclosed |
| US-20200360326-A1 | Aqueous Liquid Composition Containing 2-Amino-3-(4-Bromobenzoyl)Phenylacetic Acid | BAUSCH & LOMB INCORPORATED | 2020-11-19 | — | — | US | disclosed |
| CN-111712238-A | Eye drops containing 2-amino-3- (4-bromobenzoyl) phenylacetic acid or its salt | 参天制药株式会社 | 2020-09-25 | — | — | CN | disclosed |
| EP-2919755-B1 | AQUEOUS LIQUID COMPOSITION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | BAUSCH & LOMB (US) | 2018-02-21 | — | — | EP | disclosed |
| US-9561277-B2 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2017-02-07 | — | — | US | disclosed |
| EP-2653159-B1 | BROMFENAC ORGANIC SALTS AND PREPARATION METHOD, COMPOSITION AND USE THEREOF | SHENYANG XINGQI PHARMACEUTICAL CO LTD (CN) | 2016-06-29 | — | — | EP | disclosed |
| EP-1808170-B1 | AQUEOUS EYE DROPS WITH ACCELERATED INTRAOCULAR MIGRATION | SENJU PHARMA CO (JP) | 2011-08-17 | — | — | EP | disclosed |
| US-20110054031-A1 | Ophthalmic NSAIDS as Adjuvants | ISTA PHARMACEUTICALS, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| EP-2247289-A2 | OPHTHALMIC NSAIDS AS ADJUVANTS | Ista Pharmaceuticals (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009105534-A2 | OPHTHALMIC NSAIDS AS ADJUVANTS | ISTA PHARMACEUTICALS (US) | 2009-08-27 | — | — | WO | disclosed |
| EP-1586316-B1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | SENJU PHARMA CO (JP) | 2008-04-30 | — | — | EP | disclosed |
| US-20070287749-A1 | BROMFENAC OPHTHALMIC FORMULATIONS AND METHODS OF USE | ISTA PHARMACEUTICALS, INC. (US) | 2007-12-13 | — | — | US | disclosed |
| EP-1808170-A1 | AQUEOUS EYE DROPS WITH ACCELERATED INTRAOCULAR MIGRATION | Senju Pharmaceutical Co., Ltd. (JP) | 2007-07-18 | — | — | EP | disclosed |
| US-20070021507-A1 | Aqueous eye drops with accelerated intraocular migration | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2007-01-25 | — | — | US | disclosed |
| US-20050239895-A1 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | SENJU PHARMACEUTICAL CO., LTD. (JP) | 2005-10-27 | — | — | US | disclosed |
| EP-1586316-A1 | AQUEOUS LIQUID PREPARATION CONTAINING 2-AMINO-3-(4-BROMOBENZOYL)PHENYLACETIC ACID | Senju Pharmaceutical Co., Ltd. (JP) | 2005-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021507-A1 | Aqueous eye drops with accelerated intraocular migration | AADAT, SLC43A1, IL6 | PTGS1 74/4885PTGS2 145/4885CA1 3134/4885 |
| US-20200360326-A1 | Aqueous Liquid Composition Containing 2-Amino-3-(4-Bromobenzoyl)Phenylacetic Acid | AADAT, UACA, IL4 | PTGS1 549/4885PTGS2 377/4885CA1 1788/4885 |
| US-20110054031-A1 | Ophthalmic NSAIDS as Adjuvants | VEGFA, ALOX5, KDR | PTGS1 15/4885PTGS2 26/4885CA1 4320/4885 |
| US-20070287749-A1 | BROMFENAC OPHTHALMIC FORMULATIONS AND METHODS OF USE | TRPC3, AADAC, FFAR3 | PTGS1 199/4885PTGS2 144/4885CA1 4309/4885 |
| US-20050239895-A1 | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid | PAOX, FFAR2, FFAR3 | PTGS1 149/4885PTGS2 60/4885CA1 4513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.