SCHEMBL5717907 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	MAPT	P10636	3/20	0.35

▸	KMT2A	Q03164	3/20	0.35

▸	MEN1	O00255	1/20	0.35

▸	HSD17B10	Q99714	1/20	0.34

▸	KDM4E	B2RXH2	1/20	0.33

▸	ALDH1A1	P00352	1/20	0.33

▸	GAA	P10253	1/20	0.33

▸	GPR139	Q6DWJ6	1/20	0.33

▸	PKM	P14618	1/20	0.33

▸	GCGR	P47871	1/20	0.33

▸	PLAU	P00749	1/20	0.32

▸	PPARA	Q07869	1/20	0.32

▸	MRGPRX4	Q96LA9	3/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5717924	0.90	LMNA (0.37)	MAPTKMT2AMEN1HSD17B10KDM4E
SCHEMBL5717880	0.90	KMT2A (0.36)	MAPTKMT2AMEN1HSD17B10KDM4E
SCHEMBL5722496	0.90	SENP5 (0.35)	MAPTKMT2AMEN1ALDH1A1GPR139
SCHEMBL5717818	0.90	HSD17B10 (0.35)	MAPTKMT2AMEN1HSD17B10KDM4E
SCHEMBL5717845	0.89	MRGPRX4 (0.38)	MRGPRX4
SCHEMBL5722552	0.88	MAPK1 (0.36)	MAPTKMT2AMEN1HSD17B10KDM4E
SCHEMBL5718073	0.88	HSD17B10 (0.36)	MAPTKMT2AMEN1HSD17B10KDM4E
SCHEMBL5717901	0.88	GPR139 (0.36)	MAPTKMT2AMEN1HSD17B10KDM4E
SCHEMBL5718006	0.87	PLAU (0.40)	MAPTKMT2AMEN1ALDH1A1PKM
SCHEMBL5718133	0.86	TNF (0.36)	KMT2AHSD17B10KDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1732533-A1	THYROID RECEPTOR AGONISTS	KARO BIO AB (SE)	2006-12-20	—	—	EP	disclosed
WO-2005092317-A1	THYROID RECEPTOR AGONISTS	KARO BIO AB (SE)	2005-10-06	—	—	WO	disclosed