SCHEMBL5720583

SCHEMBL5720583

ClC(Cl)(Cl)c1ccncc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.50
CYP19A1 P11511 4/20 0.46
LMNA P02545 2/20 0.42
MAPT P10636 2/20 0.42
USP2 O75604 1/20 0.41
RAB9A P51151 1/20 0.41
KIF11 P52732 3/20 0.40
HDAC8 Q9BY41 2/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP2D6 P10635 1/20 0.38
CHRM1 P11229 1/20 0.38
MAPK1 P28482 1/20 0.38
KCNA1 Q09470 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7265049 0.79 CYP19A1 (0.44) TSHRCYP19A1LMNAMAPTUSP2
Pyridine SCHEMBL28116441 0.78 TSHR (0.70) TSHRCYP19A1LMNAMAPTUSP2
SCHEMBL28320267 0.77 CYP19A1 (0.43) TSHRCYP19A1LMNAMAPTUSP2
SCHEMBL10852484 0.77 KIF11 (0.48) TSHRCYP19A1LMNAMAPTUSP2
SCHEMBL14486637 0.77 KIF11 (0.46) TSHRCYP19A1LMNAMAPTUSP2
SCHEMBL12909254 0.77 KIF11 (0.48) TSHRCYP19A1LMNAMAPTUSP2
SCHEMBL545084 0.75 TSHR (0.67) TSHRCYP19A1LMNAMEN1KMT2A
SCHEMBL9816151 0.75 TSHR (0.67) TSHRCYP19A1LMNAMEN1KMT2A
Hydrochloric Acid SCHEMBL27769295 0.75 KIF11 (0.44) TSHRCYP19A1LMNAMAPTUSP2
SCHEMBL5309862 0.75 CYP19A1 (0.50) TSHRCYP19A1USP2RAB9AKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0204848-B1 PREPARATION OF SYMMETRICAL TETRACHLOROPYRIDINE FROM CHLORINATED BETA - (TRICHLOROMETHYL) PYRIDINES EMPLOYING A CATALYST THE DOW CHEMICAL COMPANY (US) 1989-11-23 EP claimed
US-12612548-B2 Method for producing inorganic fluoride luminescent material NICHIA CORPORATION (JP) 2026-04-28 US disclosed
US-20230220275-A1 METHOD FOR PRODUCING INORGANIC FLUORIDE LUMINESCENT MATERIAL NICHIA CORPORATION (JP) 2023-07-13 US disclosed
US-20230142294-A1 PRODUCTION METHOD OF INORGANIC FLUORIDE LUMINESCENT MATERIAL NICHIA CORPORATION (JP) 2023-05-11 US disclosed
CN-110195239-A A kind of method that more chloromethyl pyridine derivative electrochemistry dechlorinations prepare aldehyde, acid 浙江工业大学 2019-09-03 CN disclosed
US-9638690-B2 Compounds and compositions for use as alkylating agent sensors and methods of use thereof THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2017-05-02 US disclosed
US-9638690-B2 Compounds and compositions for use as alkylating agent sensors and methods of use thereof THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2017-05-02 US disclosed
US-9638690-B2 Compounds and compositions for use as alkylating agent sensors and methods of use thereof THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2017-05-02 US disclosed
US-20160131641-A1 COMPOUNDS AND COMPOSITIONS FOR USE AS ALKYLATING AGENT SENSORS AND METHODS OF USE THEREOF THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2016-05-12 US disclosed
US-20160131641-A1 COMPOUNDS AND COMPOSITIONS FOR USE AS ALKYLATING AGENT SENSORS AND METHODS OF USE THEREOF THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2016-05-12 US disclosed
US-20160131641-A1 COMPOUNDS AND COMPOSITIONS FOR USE AS ALKYLATING AGENT SENSORS AND METHODS OF USE THEREOF THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2016-05-12 US disclosed
EP-1072576-B1 FLUORINATING AGENT, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF MITSUI CHEMICALS INC (JP) 2006-08-02 EP disclosed
US-6417361-B1 HYDROGEN FLUORIDE AND N,N'-DIALKYLCYCLIC UREA COMPOUND MITSUI CHEMICALS, INC. (JP) 2002-07-09 US disclosed
EP-1072576-A1 FLUORINATING AGENT, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF Mitsui Chemicals, Inc. (JP) 2001-01-31 EP disclosed
US-5166352-A Pyridinecarboxylic acid chlorides from (trichloromethyl)pyridines DOWELANCO (US) 1992-11-24 US disclosed
EP-0204848-A1 Preparation of symmetrical tetrachloropyridine from chlorinated beta - (trichloromethyl) pyridines employing a catalyst THE DOW CHEMICAL COMPANY (US) 1986-12-17 EP disclosed
EP-0004435-B1 ETHERS OF 4-HALOMETHYLPYRIDINES, FUNGICIDAL COMPOSITIONS AND METHOD FOR PROTECTING PLANTS FROM FUNGAL DISEASE THE DOW CHEMICAL COMPANY (US) 1981-07-01 EP disclosed
US-4022897-A 4H-PYRIDO(1,2-A) PYRIMIDIN-4-ONE DERIVATIVES E. R. SQUIBB & SONS, INC. (US) 1977-05-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160131641-A1 COMPOUNDS AND COMPOSITIONS FOR USE AS ALKYLATING AGENT SENSORS AND METHODS OF USE THEREOF MGMT, MCL1, OGG1 TSHR 3834/4885CYP19A1 2038/4885LMNA 1869/4885
US-12612548-B2 Method for producing inorganic fluoride luminescent material FLNA, F7, NPM1 TSHR 135/4885CYP19A1 3415/4885LMNA 1543/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.