Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 3/20 | 0.54 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.46 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444811 | 0.98 | ALDH1A1 (0.56) | MCL1ACMSDALDH1A1HSD17B10HIF1A | |
| SCHEMBL31742566 | 0.91 | MCL1 (0.54) | MCL1ACMSDALDH1A1HSD17B10HIF1A | |
| SCHEMBL1373671 | 0.90 | MCL1 (0.50) | MCL1ACMSDALDH1A1HSD17B10HIF1A | |
| SCHEMBL30274189 | 0.89 | GSTP1 (0.57) | MCL1ACMSDALDH1A1HSD17B10CA12 | |
| SCHEMBL598962 | 0.89 | GSTP1 (0.57) | MCL1ACMSDALDH1A1HSD17B10CA12 | |
| SCHEMBL20124391 | 0.89 | MCL1 (0.53) | MCL1ACMSDCA12CA1CA2 | |
| SCHEMBL25177116 | 0.87 | MCL1 (0.51) | MCL1ACMSDALDH1A1HSD17B10HIF1A | |
| SCHEMBL57494 | 0.87 | ALDH1A1 (0.54) | MCL1ACMSDALDH1A1HSD17B10HIF1A | |
| SCHEMBL29195637 | 0.87 | MCL1 (0.51) | MCL1ACMSDALDH1A1HSD17B10HIF1A | |
| SCHEMBL29986101 | 0.87 | MCL1 (0.51) | MCL1ACMSDALDH1A1HSD17B10HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3287506-B1 | PHENANTHRENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-02-26 | — | — | EP | disclosed |
| EP-1797158-B1 | PHENANTHRENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-05-01 | — | — | EP | disclosed |
| EP-3287506-A1 | PHENANTHRENE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-28 | — | — | EP | disclosed |
| CN-102775279-B | 2,7-dibromo-9-hydroxyl phenanthrene derivatives and preparation method thereof | INST CHEMISTRY CO LTD HENAN ACADEMY OF SCIENCES | 2014-03-05 | — | — | CN | disclosed |
| CN-103254044-A | 2,7-dibromide-9,10 substituted-phenanthrene derivatives | INST CHEMISTRY CO LTD HENAN ACADEMY OF SCIENCES | 2013-08-21 | — | — | CN | disclosed |
| US-8129037-B2 | Phenanthrene derivative | MERCK PATENT GMBH (DE) | 2012-03-06 | — | — | US | disclosed |
| US-20090026919-A1 | PHENANTHRENE DERIVATIVE | MERCK PATEN GMBH PATENTS & SCIENTIFIC INFORMATION (DE) | 2009-01-29 | — | — | US | disclosed |
| EP-1797158-A1 | PHENANTHRENE DERIVATIVE | Merck Patent GmbH (DE) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006039982-A1 | PHENANTHRENE DERIVATIVE | MERCK PATENT GMBH (DE) | 2006-04-20 | — | — | WO | disclosed |
| EP-1645610-A1 | Phenanthrene derivatives | Covion Organic Semiconductors GmbH (DE) | 2006-04-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090026919-A1 | PHENANTHRENE DERIVATIVE | LEF1, CRY1, WNT1 | MCL1 1329/4885ACMSD 1623/4885ALDH1A1 262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.