Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | AHR | P35869 | 1/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HK1 | P19367 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2510066 | 0.83 | NPC1 (0.55) | ALOX15HSD17B10CYP1A2AHRPDK2 | |
| Hydrochloric Acid SCHEMBL6137385 | 0.81 | NPC1 (0.53) | ALOX15HSD17B10CYP1A2AHRPDK2 | |
| SCHEMBL4391893 | 0.79 | CYP2A6 (0.52) | ALOX15HSD17B10CYP1A2AHRPDK2 | |
| SCHEMBL8805855 | 0.79 | BRPF1 (0.47) | ALOX15HSD17B10CYP1A2AHRPDK2 | |
| SCHEMBL2087881 | 0.77 | ALOX15 (1.00) | ALOX15HSD17B10CYP1A2AHRPDK2 | |
| SCHEMBL31546300 | 0.77 | ALOX15 (1.00) | ALOX15HSD17B10CYP1A2AHRPDK2 | |
| SCHEMBL30668800 | 0.76 | — | — | |
| SCHEMBL2041999 | 0.76 | — | — | |
| SCHEMBL1828551 | 0.76 | — | — | |
| SCHEMBL5193435 | 0.74 | ALOX15 (0.57) | ALOX15HSD17B10AHRPDK2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109293493-A | With the inhibition active novel benzhydryl class compound of mycobacterium tuberculosis | 清华大学 | 2019-02-01 | — | — | CN | claimed |
| CN-103772276-B | 2-[6-methoxyl group-3-(2,3-dichlorophenyl) methyl-4-oxo-Isosorbide-5-Nitrae-dihydro-1 (4H)-quinolyl] preparation method of acetic acid | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2016-05-11 | — | — | CN | claimed |
| CN-103772276-A | Preparation method of 2-(6-methoxy-3-(2, 3-dichlorophenyl) methyl-4-oxo-1, 4-dihydro-1(4H)-quinolyl) acetic acid | UNIV SHENYANG PHARMACEUTICAL | 2014-05-07 | — | — | CN | claimed |
| CN-101723893-A | 2,3-disubstituted-2,3-dihydro quinoline ketone chiral compound as well as preparation method and application thereof | SHANGHAI INST ORGANIC CHEM | 2010-06-09 | — | — | CN | claimed |
| US-10000535-B2 | Template-fixed peptidomimetics | POLYPHOR LTD. (CH) | 2018-06-19 | — | — | US | disclosed |
| CN-105418497-B | The synthesis technique of 3 chlorine octahydro 2 (1H) quinolinones | 大连鼎燕医药化工有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-103772276-B | 2-[6-methoxyl group-3-(2,3-dichlorophenyl) methyl-4-oxo-Isosorbide-5-Nitrae-dihydro-1 (4H)-quinolyl] preparation method of acetic acid | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2016-05-11 | — | — | CN | disclosed |
| CN-103772276-B | 2-[6-methoxyl group-3-(2,3-dichlorophenyl) methyl-4-oxo-Isosorbide-5-Nitrae-dihydro-1 (4H)-quinolyl] preparation method of acetic acid | SHENYANG PHARMACEUTICAL UNIVERSITY (CN) | 2016-05-11 | — | — | CN | disclosed |
| CN-105418497-A | Synthesis technology of 3-chloro-octahydro-2(1H)-quinolinone | DALIAN DINGYAN MEDICINE CHEMICAL CO LTD | 2016-03-23 | — | — | CN | disclosed |
| US-20160046625-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC (US) | 2016-02-18 | — | — | US | disclosed |
| US-9115127-B2 | Benzimidazole and azabenzimidazole compounds that inhibit anaplastic lymphoma kinase | AMGEN INC. (US) | 2015-08-25 | — | — | US | disclosed |
| EP-2600874-B1 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC (US) | 2015-03-04 | — | — | EP | disclosed |
| US-5696133-A | ADMINISTERING COMPOUND WHICH MODULATES ACTIVITY OF PROGESTERONE RECEPTOR | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1997-12-09 | — | — | US | disclosed |
| US-5693647-A | Steroid receptor modulator compounds and methods | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1997-12-02 | — | — | US | disclosed |
| US-5693646-A | Steroid receptor modulator compounds and methods | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1997-12-02 | — | — | US | disclosed |
| US-5688808-A | Steroid receptor modulator compounds and methods | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1997-11-18 | — | — | US | disclosed |
| US-5688810-A | Steroid receptor modulator compounds and methods | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0800519-A1 | STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS, INC. (US) | 1997-10-15 | — | — | EP | disclosed |
| CN-1150799-A | Benzoheterocyclic derivatives | OTSUKA PHARMA CO LTD (JP) | 1997-05-28 | — | — | CN | disclosed |
| WO-1996019458-A2 | STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046625-A1 | BENZIMIDAZOLE AND AZABENZIMIDAZOLE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | BCL6, DCK, FLI1 | ALOX15 3658/4885HSD17B10 1208/4885CYP1A2 1226/4885 |
| US-10000535-B2 | Template-fixed peptidomimetics | CCR10, CXCR3, CCR5 | ALOX15 4255/4885HSD17B10 2492/4885CYP1A2 4687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.