Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | FABP7 | O15540 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5728312 | 0.79 | TP53 (0.46) | MAOBRAB9ANPC1POLBTP53 | |
| SCHEMBL5740873 | 0.77 | HPGD (0.40) | TP53KDM1ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5728176 | 0.72 | CCNT1 (0.42) | MAOBTP53KDM1AMAOAALDH1A1 | |
| SCHEMBL5728418 | 0.70 | TACR1 (0.36) | MAOBTP53KDM1AMAOAALDH1A1 | |
| SCHEMBL4678473 | 0.69 | FAAH (0.66) | MAOBRAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL5728454 | 0.66 | L3MBTL1 (0.39) | POLBALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL5728175 | 0.65 | GAA (0.44) | RAB9ANPC1TP53SMN1; SMN2ALDH1A1 | |
| SCHEMBL9407475 | 0.65 | LMNA (0.50) | MAOBALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL20911008 | 0.64 | RAB9A (0.75) | MAOBRAB9ANPC1POLBSMN1; SMN2 | |
| SCHEMBL3250688 | 0.64 | ALDH1A1 (0.38) | RAB9APOLBTP53SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | Aventis Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014555-A1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-02-17 | — | — | WO | disclosed |