SCHEMBL573520

SCHEMBL573520

CN(C)S(=O)(=O)c1cc(C(=O)O)cc([N+](=O)[O-])c1Cl

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 4/20 0.47
VCAM1 P19320 1/20 0.47
TSHR P16473 2/20 0.43
CASP6 P55212 1/20 0.43
TPMT P51580 1/20 0.43
ALDH1A1 P00352 5/20 0.41
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
POLB P06746 2/20 0.40
KDM4E B2RXH2 2/20 0.40
LMNA P02545 2/20 0.40
PKM P14618 1/20 0.40
PDE2A O00408 1/20 0.40
PDE5A O76074 1/20 0.40
CYP3A4 P08684 1/20 0.40
ALOX15 P16050 1/20 0.40
NFKB1 P19838 1/20 0.40
APEX1 P27695 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL573855 0.85 VCAM1 (0.52) VCAM1TSHRALDH1A1MEN1KMT2A
SCHEMBL7826598 0.84 VCAM1 (0.49) HCAR3VCAM1TSHRCASP6TPMT
SCHEMBL135289 0.82 CASP6 (0.47) HCAR3VCAM1TSHRCASP6TPMT
Methylamine SCHEMBL11877019 0.82 TSHR (0.44) HCAR3VCAM1TSHRCASP6TPMT
SCHEMBL573259 0.81 ALDH1A1 (0.57) HCAR3VCAM1TSHRCASP6TPMT
SCHEMBL31108456 0.81 ALDH1A1 (0.57) HCAR3VCAM1TSHRCASP6TPMT
SCHEMBL11542928 0.81 HCAR3 (0.42) HCAR3TSHRCASP6TPMTALDH1A1
SCHEMBL11847710 0.81 HCAR3 (0.47) HCAR3VCAM1TSHRCASP6TPMT
SCHEMBL30241160 0.78 MAPT (0.44) HCAR3VCAM1TSHRCASP6TPMT
SCHEMBL28945979 0.78 MAPT (0.44) HCAR3VCAM1TSHRCASP6TPMT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2598478-A2 ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE Neurotherapeutics Pharma, Inc. (US) 2013-06-05 EP disclosed
WO-2012018635-A2 ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE NEUROTHERAPEUTICS PHARMA, INC. (US) 2012-02-09 WO disclosed
WO-2012018635-A2 ARYLSULFONAMIDE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE NEUROTHERAPEUTICS PHARMA, INC. (US) 2012-02-09 WO disclosed
US-3985777-A Sulphamyl-benzoic acid derivatives LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) 1976-10-12 US disclosed