Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 4/20 | 0.41 |
| ▸ | CA1 | P00915 | 4/20 | 0.41 |
| ▸ | CA2 | P00918 | 4/20 | 0.41 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31108456 | 1.00 | ALDH1A1 (0.57) | ALDH1A1CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL135289 | 0.86 | CASP6 (0.47) | ALDH1A1CYP1A2CYP2D6CYP2C19LMNA | |
| Methylamine SCHEMBL11877019 | 0.85 | TSHR (0.44) | ALDH1A1CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL7826598 | 0.85 | VCAM1 (0.49) | ALDH1A1CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL13543308 | 0.84 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2D6CYP2C19MEN1 | |
| SCHEMBL16581035 | 0.83 | LMNA (0.51) | ALDH1A1CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL573521 | 0.83 | VCAM1 (0.54) | ALDH1A1CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL2876091 | 0.82 | LMNA (0.46) | ALDH1A1CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL13283938 | 0.82 | LMNA (0.46) | ALDH1A1CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL3146159 | 0.82 | CASP6 (0.60) | ALDH1A1LMNACASP6TPMTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119954694-A | Bumetat preparation process of nylon | 海南卓科制药有限公司 | 2025-05-09 | — | — | CN | claimed |
| CN-117534594-A | Bumetanide intermediate and preparation method thereof | 宁波大红鹰药业股份有限公司 | 2024-02-09 | — | — | CN | claimed |
| CN-100494172-C | Method of preparing 2-chloro-3-nitro-5-carboxyl benzenesulfonamide | SUZHOU LIXIN PHARMACY CO LTD (CN) | 2009-06-03 | — | — | CN | claimed |
| CN-101033206-A | Method of preparing 2-chloro-3-nitro-5-carboxyl benzenesulfonamide | SUZHOU LIXIN PHARMACY CO LTD (CN) | 2007-09-12 | — | — | CN | claimed |
| EP-0068408-A1 | Antiviral compositions and a method for treating virus diseases | Mochida Pharmaceutical Co., Ltd. (JP) | 1983-01-05 | — | — | EP | claimed |
| EP-0068407-A1 | Aminosulfonylbenzoic acid derivatives | HODOGAYA CHEMICAL CO., LTD. (JP) | 1983-01-05 | — | — | EP | claimed |
| US-20260132103-A1 | Bumetanide Derivatives for the Therapy of Stroke and Other Neurological Diseases/Disorders Involving NKCCs | UNIV OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2026-05-14 | — | — | US | disclosed |
| CN-119954694-B | Bumetat preparation process of nylon | 海南卓科制药有限公司 | 2025-10-24 | — | — | CN | disclosed |
| CN-119954694-A | Bumetat preparation process of nylon | 海南卓科制药有限公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-119954694-A | Bumetat preparation process of nylon | 海南卓科制药有限公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-117567326-A | Preparation method of bumetanide | 山东诺明康药物研究院有限公司 | 2024-02-20 | — | — | CN | disclosed |
| CN-117534594-A | Bumetanide intermediate and preparation method thereof | 宁波大红鹰药业股份有限公司 | 2024-02-09 | — | — | CN | disclosed |
| CN-117534594-A | Bumetanide intermediate and preparation method thereof | 宁波大红鹰药业股份有限公司 | 2024-02-09 | — | — | CN | disclosed |
| US-4093735-A | DIURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4010273-A | DIURETICS, SALURETICS | HOECHST AKTIENGESELLSCHAFT (DT) | 1977-03-01 | — | — | US | disclosed |
| US-3992440-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1976-11-16 | — | — | US | disclosed |
| US-3985777-A | Sulphamyl-benzoic acid derivatives | LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB (DK) | 1976-10-12 | — | — | US | disclosed |
| US-3982018-A | DIURETICS | CIBA-GEIGY CORPORATION (US) | 1976-09-21 | — | — | US | disclosed |
| US-3939267-A | DIURETIC | CIBA-GEIGY CORPORATION (US) | 1976-02-17 | — | — | US | disclosed |
| US-3933906-A | DIURETIC | CIBA-GEIGY CORPORATION (US) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260132103-A1 | Bumetanide Derivatives for the Therapy of Stroke and Other Neurological Diseases/Disorders Involving NKCCs | CLIC1, SLC6A1, KCNC1 | ALDH1A1 670/4885CYP1A2 3368/4885CYP2D6 2481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.