Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5735982 | 0.93 | MAOA (0.37) | ACLYMAOAADRA1AFFAR2MAPT | |
| SCHEMBL7994515 | 0.90 | ACLY (0.41) | ACLYMAOAADRA1AFFAR2MAPT | |
| SCHEMBL6790401 | 0.90 | ACLY (0.39) | ACLYMAOAADRA1AFFAR2MAPT | |
| SCHEMBL5735113 | 0.81 | GAA (0.43) | ACLYMAPTTP53POLBALDH1A1 | |
| SCHEMBL1599472 | 0.81 | ACLY (0.40) | ACLYMAPTNPC1GAATSHR | |
| SCHEMBL3153668 | 0.81 | MAOA (0.37) | MAOAADRA1AFFAR2MAPTCASP3 | |
| SCHEMBL5736818 | 0.80 | ACLY (0.39) | ACLYNPC1GAARAB9A | |
| SCHEMBL7995977 | 0.80 | ACLY (0.39) | ACLYMAPTTP53POLBNPC1 | |
| SCHEMBL6614261 | 0.79 | MAPT (0.47) | MAOAADRA1AMAPTTP53NPC1 | |
| SCHEMBL7995986 | 0.79 | MAPT (0.43) | MAPTTP53ALDH1A1THRBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686128-A2 | Isothiazole derivatives and their use as pesticides | Syngenta Limited (GB) | 2006-08-02 | — | — | EP | disclosed |
| EP-1265892-B1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LTD (GB) | 2006-01-18 | — | — | EP | disclosed |
| US-6703347-B2 | INSECTICIDES, FUNGICIDES, NEMATOCIDES, MOLLUSCICIDES, AND MITICIDES FOR PLANTS | SYNGENTA LIMITED (GB) | 2004-03-09 | — | — | US | disclosed |
| US-20030207926-A1 | Isothiazole derivatives and their use as pesticides | SYNGENTA LIMITED (GB) | 2003-11-06 | — | — | US | disclosed |
| EP-1265892-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | Syngenta Limited (GB) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001055144-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LIMITED (GB) | 2001-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207926-A1 | Isothiazole derivatives and their use as pesticides | CBR1, CBR3, CYP1B1 | ACLY 2189/4885MAOA 2339/4885ADRA1A 370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.