Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | AGPAT2 | O15120 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | BUB1 | O43683 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1599472 | 0.81 | ACLY (0.40) | ACLYMEN1NPC1RAB9AKMT2A | |
| SCHEMBL5735113 | 0.81 | GAA (0.43) | ACLYKDM4EPPARGP2RY14GAA | |
| SCHEMBL7994515 | 0.81 | ACLY (0.41) | ACLYKDM4EMEN1NPC1RAB9A | |
| SCHEMBL7995977 | 0.80 | ACLY (0.39) | ACLYAGPAT2MEN1NPC1RAB9A | |
| SCHEMBL5735580 | 0.80 | ACLY (0.39) | ACLYNPC1RAB9AGAA | |
| SCHEMBL7995986 | 0.79 | MAPT (0.43) | KDM4ECETPPPARG | |
| SCHEMBL6790401 | 0.79 | ACLY (0.39) | ACLYMEN1NPC1RAB9AKMT2A | |
| SCHEMBL6790398 | 0.78 | GAA (0.50) | ACLYKDM4EP2RY14GAA | |
| SCHEMBL8001808 | 0.78 | GAA (0.42) | P2RY14GAA | |
| SCHEMBL5735982 | 0.76 | MAOA (0.37) | ACLYKDM4ENPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686128-A2 | Isothiazole derivatives and their use as pesticides | Syngenta Limited (GB) | 2006-08-02 | — | — | EP | disclosed |
| EP-1265892-B1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LTD (GB) | 2006-01-18 | — | — | EP | disclosed |
| US-6703347-B2 | INSECTICIDES, FUNGICIDES, NEMATOCIDES, MOLLUSCICIDES, AND MITICIDES FOR PLANTS | SYNGENTA LIMITED (GB) | 2004-03-09 | — | — | US | disclosed |
| US-20030207926-A1 | Isothiazole derivatives and their use as pesticides | SYNGENTA LIMITED (GB) | 2003-11-06 | — | — | US | disclosed |
| EP-1265892-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | Syngenta Limited (GB) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001055144-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LIMITED (GB) | 2001-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207926-A1 | Isothiazole derivatives and their use as pesticides | CBR1, CBR3, CYP1B1 | ACLY 2189/4885AGPAT2 1916/4885PTGES 3295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.