SCHEMBL5739733

SCHEMBL5739733

Cc1ccc(S([O])(=O)=O)cc1OS(=O)(=O)c1ccc2ccccc2c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 1/20 0.48
L3MBTL1 Q9Y468 4/20 0.48
TDP1 Q9NUW8 2/20 0.48
HTT P42858 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
LMNA P02545 2/20 0.48
GAA P10253 2/20 0.45
MAPK1 P28482 2/20 0.45
PKM P14618 1/20 0.45
PKLR P30613 1/20 0.45
MEN1 O00255 5/20 0.43
KMT2A Q03164 5/20 0.43
MAPT P10636 3/20 0.43
ALDH1A1 P00352 2/20 0.40
KDM4E B2RXH2 1/20 0.40
ENPP2 Q13822 1/20 0.39
TUBB4A P04350 1/20 0.39
TUBB P07437 1/20 0.39
TUBA3C P0DPH7 1/20 0.39
TUBA1B P68363 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2064679 0.79 L3MBTL1 (0.59) L3MBTL1TDP1HTTSMN1; SMN2LMNA
SCHEMBL294027 0.78 LMNA (0.65) L3MBTL1SMN1; SMN2LMNAPKMPKLR
SCHEMBL18431364 0.77 HTR6 (0.46) HTR6L3MBTL1TDP1HTTSMN1; SMN2
SCHEMBL6234556 0.75 TSHR (0.38) TDP1SMN1; SMN2LMNAGAAMAPK1
SCHEMBL11436678 0.74 MEN1 (0.54) HTR6L3MBTL1TDP1HTTSMN1; SMN2
SCHEMBL22558337 0.74 L3MBTL1 (0.62) HTR6L3MBTL1TDP1HTTSMN1; SMN2
SCHEMBL2473745 0.73 L3MBTL1 (0.60) L3MBTL1TDP1HTTSMN1; SMN2LMNA
SCHEMBL28296929 0.73 L3MBTL1 (0.75) L3MBTL1TDP1HTTSMN1; SMN2LMNA
SCHEMBL7553637 0.72 SMN1; SMN2 (0.52) HTR6L3MBTL1TDP1HTTSMN1; SMN2
SCHEMBL7114641 0.72 SMN1; SMN2 (0.52) HTR6L3MBTL1TDP1HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1658264-A2 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES Neurochem (International) Limited (CH) 2006-05-24 EP disclosed
EP-1635909-A2 TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES Neurochem (International) Limited (CH) 2006-03-22 EP disclosed
WO-2005000406-A2 TREATMENT OF AMYLOID- AND EPILEPTOGENESIS-ASSOCIATED DISEASES NEUROCHEM (INTERNATIONAL) LIMITED (CH) 2005-01-06 WO disclosed
WO-2004113277-A2 METHODS AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES NEUROCHEM (INTERNATIONAL) LIMITED (CH) 2004-12-29 WO disclosed