Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.51 |
| ▸ | PDE4A | P27815 | 5/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | TPH1 | P17752 | 2/20 | 0.41 |
| ▸ | TPH2 | Q8IWU9 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5739462 | 0.80 | ADORA3 (0.56) | ADORA3ADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL5740117 | 0.76 | ADORA3 (0.52) | ADORA3ADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL5740691 | 0.74 | ADORA3 (0.50) | ADORA3ADORA2AADORA2BADORA1HSD17B10 | |
| SCHEMBL11181037 | 0.73 | ALDH1A1 (0.52) | ADORA2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5741533 | 0.71 | ADORA1 (0.50) | ADORA3ADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL5511769 | 0.69 | ADORA3 (1.00) | ADORA3ADORA2AADORA1HPGDHSD17B10 | |
| SCHEMBL7607643 | 0.68 | PDE4A (0.74) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL9765885 | 0.68 | ADORA2B (1.00) | ADORA3ADORA2AADORA2BADORA1HPGD | |
| SCHEMBL5741099 | 0.68 | ADORA2B (0.41) | ADORA3ADORA2AADORA2BPDE4APDE4B | |
| SCHEMBL31714719 | 0.66 | ADORA3 (0.56) | ADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252780-A1 | Fused pyrimidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-11-09 | — | — | US | disclosed |
| EP-1637532-A1 | FUSED PYRIMIDINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252780-A1 | Fused pyrimidine derivatives | INSR, GPR119, NPY4R | ADORA3 275/4885ADORA2A 1417/4885ADORA2B 1074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.