Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CRHBP | P24387 | 2/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741135 | 0.87 | MAPT (0.61) | LMNACRHBPCRHR2SMN1; SMN2MAPT | |
| SCHEMBL22616898 | 0.80 | KMT2A (0.62) | LMNACRHBPCRHR2SMN1; SMN2MAPT | |
| SCHEMBL17877575 | 0.80 | CRHBP (0.48) | LMNACRHBPCRHR2SMN1; SMN2MAPT | |
| SCHEMBL22626849 | 0.78 | GRIN2B (0.48) | LMNASMN1; SMN2MAPTMEN1ALDH1A1 | |
| SCHEMBL942454 | 0.77 | LMNA (0.42) | LMNACRHBPCRHR2SMN1; SMN2MAPT | |
| SCHEMBL27455408 | 0.77 | CRHBP (0.66) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL30954002 | 0.77 | CRHBP (0.66) | CRHBPCRHR2SMN1; SMN2MAPTGFER | |
| SCHEMBL5741147 | 0.74 | HRH4 (0.49) | LMNASMN1; SMN2MEN1ALDH1A1KMT2A | |
| SCHEMBL605893 | 0.74 | HRH4 (0.60) | HRH3HRH4 | |
| SCHEMBL5742837 | 0.74 | HRH4 (0.50) | LMNASMN1; SMN2MAPTGFERHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220313701-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2022-10-06 | — | — | US | claimed |
| CN-114341125-A | TREX1 modulators | 星座制药公司 | 2022-04-12 | — | — | CN | claimed |
| EP-3962907-A1 | MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2022-03-09 | — | — | EP | claimed |
| WO-2020223590-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2020-11-05 | — | — | WO | claimed |
| EP-1654249-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005014573-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-02-17 | — | — | WO | claimed |
| US-20050032810-A1 | Novel anthelmintic and insecticidal compositions | PHARMACIA AND UPJOHN COMPANY | 2005-02-10 | — | — | US | claimed |
| US-20220313701-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. | 2022-10-06 | — | — | US | disclosed |
| CN-114341125-A | TREX1 modulators | 星座制药公司 | 2022-04-12 | — | — | CN | disclosed |
| EP-3962907-A1 | MODULATORS OF TREX1 | Constellation Pharmaceuticals, Inc. (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020223590-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2020-11-05 | — | — | WO | disclosed |
| EP-1654249-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | Pharmacia & Upjohn Company LLC (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005014573-A1 | ANTHELMINTIC AND INSECTICIDE PYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-02-17 | — | — | WO | disclosed |
| US-20050032810-A1 | Novel anthelmintic and insecticidal compositions | PHARMACIA AND UPJOHN COMPANY | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220313701-A1 | MODULATORS OF TREX1 | TEAD1, TREH, TSNAX | LMNA 1336/4885CRHBP 2919/4885CRHR2 3548/4885 |
| US-20050032810-A1 | Novel anthelmintic and insecticidal compositions | ACHE, DHX29, DHX35 | LMNA 3571/4885CRHBP 4330/4885CRHR2 4871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.