Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.35 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283341 | 0.81 | HSD17B1 (0.45) | ALDH1A1CYP1A2HSD17B10 | |
| SCHEMBL21647115 | 0.81 | BIRC5 (0.36) | MAOBRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL11512521 | 0.81 | MAP4K4 (0.46) | ALDH1A1MEN1KMT2AMETAP2HPGD | |
| SCHEMBL5182575 | 0.79 | ALDH1A1 (0.50) | RAB9ASMN1; SMN2TP53ALDH1A1HPGD | |
| SCHEMBL1431628 | 0.78 | ALDH1A1 (0.41) | MAOBRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL5085470 | 0.77 | RAB9A (0.37) | MAOBRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL29398181 | 0.77 | RAB9A (0.50) | MAOBRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL5805651 | 0.77 | RAB9A (0.50) | MAOBRAB9ANPC1SMN1; SMN2TP53 | |
| SCHEMBL5584043 | 0.76 | LMNA (0.31) | ALDH1A1MAPK1 | |
| SCHEMBL28015325 | 0.75 | GABRG2 (0.34) | MAOBRAB9ANPC1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720556-A2 | NOVEL 2'-C-METHYL NUCLEOSIDE DERIVATIVES | Merck & Co., Inc. (US) | 2006-11-15 | — | — | EP | claimed |
| WO-2005084192-A2 | NOVEL 2’-C-METHYL NUCLEOSIDE DERIVATIVES | MERCK & CO., INC. (US) | 2005-09-15 | — | — | WO | claimed |
| US-5869521-A | Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith | ADOLOR CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |