Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.46 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP9 | P55211 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28641177 | 0.84 | PNMT (0.40) | PNMTTDP2CASP3CASP7CASP9 | |
| SCHEMBL6393796 | 0.79 | PNMT (0.42) | PNMTTDP2CASP3CASP7CASP9 | |
| SCHEMBL4611913 | 0.77 | NAAA (0.42) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL8467847 | 0.76 | PNMT (0.44) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL4942730 | 0.75 | GPR39 (0.46) | NPC1RAB9ACRBNDDB1IDO1 | |
| SCHEMBL1929688 | 0.71 | CRBN (0.44) | CREBBPBRD4CRBNDDB1 | |
| SCHEMBL10352631 | 0.71 | ALDH1A1 (0.46) | TDP2NPC1RAB9ACRBNDDB1 | |
| SCHEMBL4816545 | 0.70 | PNMT (0.54) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL7538016 | 0.70 | PNMT (0.62) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL3979804 | 0.70 | PNMT (0.67) | PNMTDRD2DRD4DRD3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682540-A1 | AZOLIDINECARBONITRILES AND THEIR USE AS DPP-IV INHIBITORS | Sankaranarayanan, Alangudi (IN) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005033106-A1 | AZOLIDINECARBONITRILES AND THEIR USE AS DPP-IV INHIBITORS | SANKARANARAYANAN ALANGUDI (IN) | 2005-04-14 | — | — | WO | disclosed |