SCHEMBL574732

SCHEMBL574732

Cl[Si](Cl)(Cl)CCCCCCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 11/20 0.52
MAOA P21397 1/20 0.50
MAPT P10636 1/20 0.48
RXFP1 Q9HBX9 1/20 0.48
MAOB P27338 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5482754 1.00 SIGMAR1 (0.52) SIGMAR1MAOAMAPTRXFP1MAOB
SCHEMBL5488263 1.00 SIGMAR1 (0.52) SIGMAR1MAOAMAPTRXFP1MAOB
SCHEMBL29118253 1.00 SIGMAR1 (0.52) SIGMAR1MAOAMAPTRXFP1MAOB
SCHEMBL3791482 1.00 SIGMAR1 (0.52) SIGMAR1MAOAMAPTRXFP1MAOB
SCHEMBL18979256 1.00 SIGMAR1 (0.52) SIGMAR1MAOAMAPTRXFP1MAOB
SCHEMBL1203381 0.98 MAOA (0.52) SIGMAR1MAOAMAPTRXFP1MAOB
SCHEMBL1599233 0.91 SIGMAR1 (0.48) SIGMAR1MAOAMAOBL3MBTL1
SCHEMBL13707239 0.84 SIGMAR1 (0.42) SIGMAR1MAOAMAPTMAOBL3MBTL1
SCHEMBL16207822 0.83 SIGMAR1 (0.50) SIGMAR1MAOAMAPTRXFP1MAOB
SCHEMBL10000437 0.83 SIGMAR1 (0.50) SIGMAR1MAOAMAPTRXFP1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117138762-A Low-loss mixed separation mode liquid chromatographic packing and preparation method and application thereof 微纯生物科技(广州)有限公司 2023-12-01 CN claimed
CN-105080492-B One kind separation alkali compounds silica gel chromatographic column filling material and preparation method thereof 浙江月旭材料科技有限公司 2017-07-11 CN claimed
EP-2567940-B1 METHOD FOR PREPARING CLAYS HAVING NOVEL PHYSICO-CHEMICAL PROPERTIES ECOLE DE BIOLOGIE IND (EBI) (FR) 2017-06-21 EP claimed
CN-105080492-A Silica gel chromatographic packing for separation of alkaline compound and preparation method of silica gel chromatographic packing ZHEJIANG YUEXU MATERIAL TECHNOLOGY CO LTD 2015-11-25 CN claimed
EP-2567940-A1 Method for preparing clays having novel physical-chemical properties Ecole De Biologie Industrielle (EBI) (FR) 2013-03-13 EP claimed
US-12623205-B2 Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution WATERS TECHNOLOGIES CORPORATION (US) 2026-05-12 US disclosed
US-12611617-B2 Chromatographic columns and separation devices comprising a superficially porous material; and use thereof for supercritical fluid chromatography and other chromatography WATERS TECHNOLOGIES CORPORATION (US) 2026-04-28 US disclosed
US-20260085155-A1 ORGANOPOLYSILOXANE COMPOUND AND PRODUCTION METHOD THEREOF JNC CORPORATION (JP) 2026-03-26 US disclosed
EP-3834927-B1 METHOD FOR PREPARING A SUPERFICIALLY POROUS MATERIAL WATERS TECHNOLOGIES CORP (US) 2026-03-25 EP disclosed
US-20250387778-A1 SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORPORATION (US) 2025-12-25 US disclosed
EP-3426390-B1 POROUS MATERIALS WITH CONTROLLED POROSITY AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORP (US) 2025-12-17 EP disclosed
EP-4353682-B1 SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS HYBRID CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION, USEFUL FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORP (US) 2025-11-12 EP disclosed
EP-2462188-A1 HIGH PURITY CHROMATROGRAPHIC MATERIALS COMPRISING AN IONIZABLE MODIFIER Waters Technologies Corporation (US) 2012-06-13 EP disclosed
WO-2012018598-A1 SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORPORATION (US) 2012-02-09 WO disclosed
WO-2012018596-A2 SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS HYBRID CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS WATERS TECHNOLOGIES CORPORATION (US) 2012-02-09 WO disclosed
WO-2011017418-A1 HIGH PURITY CHROMATROGRAPHIC MATERIALS COMPRISING AN IONIZABLE MODIFIER WATERS TECHNOLOGIES CORPORATION (US) 2011-02-10 WO disclosed
US-20100102299-A1 ORGANIC SEMICONDUCTOR COMPOSITE, ORGANIC TRANSISTOR MATERIAL AND ORGANIC FIELD EFFECT TRANSISTOR TORAY INDUSTRIES, INC. (JP) 2010-04-29 US disclosed
EP-2109162-A1 ORGANIC SEMICONDUCTOR COMPOSITE, ORGANIC TRANSISTOR MATERIAL AND ORGANIC FIELD EFFECT TRANSISTOR Toray Industries, Inc. (JP) 2009-10-14 EP disclosed
US-7291747-B2 Silicon compounds and process for preparation thereof CHISSO CORPORATION (JP) 2007-11-06 US disclosed
US-20040143081-A1 Novel silicon compounds and process for preparation thereof JNC CORPORATION (JP) 2004-07-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12611617-B2 Chromatographic columns and separation devices comprising a superficially porous material; and use thereof for supercritical fluid chromatography and other chromatography F11, F12, F2 SIGMAR1 77/4885MAOA 1451/4885MAPT 2990/4885
US-20260085155-A1 ORGANOPOLYSILOXANE COMPOUND AND PRODUCTION METHOD THEREOF FUCA1, MAN2B1, IDUA SIGMAR1 374/4885MAOA 3765/4885MAPT 4395/4885
US-12623205-B2 Superficially porous materials comprising a substantially nonporous hybrid core having narrow particle size distribution ZYX, FGB, F11 SIGMAR1 181/4885MAOA 1808/4885MAPT 2856/4885
US-20250387778-A1 SUPERFICIALLY POROUS MATERIALS COMPRISING A SUBSTANTIALLY NONPOROUS CORE HAVING NARROW PARTICLE SIZE DISTRIBUTION; PROCESS FOR THE PREPARATION THEREOF; AND USE THEREOF FOR CHROMATOGRAPHIC SEPARATIONS C1S, C9, C1R SIGMAR1 102/4885MAOA 3982/4885MAPT 4645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.