Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672923 | 0.81 | GAA (0.48) | SMN1; SMN2LMNAGAATHRBKDM4E | |
| SCHEMBL5666592 | 0.81 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAGAATHRBKDM4E | |
| SCHEMBL5885170 | 0.80 | LMNA (0.38) | SMN1; SMN2LMNAGAATHRBKDM4E | |
| SCHEMBL5885167 | 0.77 | LMNA (0.39) | SMN1; SMN2LMNAGAATHRBKDM4E | |
| SCHEMBL10074441 | 0.77 | HDAC1 (0.62) | SMN1; SMN2LMNAGAATHRBKDM4E | |
| SCHEMBL3013154 | 0.75 | ALDH1A1 (0.61) | SMN1; SMN2LMNAGAATHRBKDM4E | |
| Hydrochloric Acid SCHEMBL28833528 | 0.74 | ALDH1A1 (0.59) | SMN1; SMN2LMNAGAATHRBKDM4E | |
| SCHEMBL5310198 | 0.73 | HDAC6 (0.54) | SMN1; SMN2LMNAGAATHRBKDM4E | |
| SCHEMBL5784350 | 0.73 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAGAATHRBKDM4E | |
| SCHEMBL65179 | 0.72 | HDAC6 (0.69) | SMN1; SMN2LMNAGAATHRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132427-B2 | Quinazolines and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2006-11-07 | — | — | US | disclosed |
| US-7019139-B2 | Quinolinones and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2006-03-28 | — | — | US | disclosed |
| EP-1408985-A4 | NOVEL PYRIDOPYRIMIDONES AND USES THEREOF | ARIAD PHARMA INC (US) | 2006-03-22 | — | — | EP | disclosed |
| US-7009054-B2 | Quinolines and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2006-03-07 | — | — | US | disclosed |
| US-6960572-B2 | Indolinones and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2005-11-01 | — | — | US | disclosed |
| EP-1408978-A4 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | ARIAD PHARMA INC (US) | 2005-07-13 | — | — | EP | disclosed |
| US-6878697-B2 | Phenylamino-pyrimidines and uses thereof | ARIAD PHARMACEUTICALS, INC. (US) | 2005-04-12 | — | — | US | disclosed |
| US-20040242611-A1 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-12-02 | — | — | US | disclosed |
| US-20040167101-A1 | Novel quinolinones and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-08-26 | — | — | US | disclosed |
| US-20040152671-A1 | Novel quinolines and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2004-08-05 | — | — | US | disclosed |
| US-6706699-B2 | FOR THERAPY OF CANCER, OSTEOPOROSIS AND OTHER DISEASES INVOLVING UNTOWARD BONE RESORPTION E.G., PAGET'S DISEASE, PRIMARY AND SECONDARY HYPERPARATHYROIDISM, HUMORAL HYPERCALCEMIA OF MALIGNANCY | ARIAD PHARMACEUTICALS, INC. | 2004-03-16 | — | — | US | disclosed |
| US-20030130234-A1 | Novel indolinones and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2003-07-10 | — | — | US | disclosed |
| US-20030114467-A1 | Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2003-06-19 | — | — | US | disclosed |
| US-20030114486-A1 | Novel quinolinones and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-06-19 | — | — | US | disclosed |
| US-20030105115-A1 | Novel pyridopyrimidines and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2003-06-05 | — | — | US | disclosed |
| US-20030105065-A1 | Novel quinolines and uses thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-06-05 | — | — | US | disclosed |
| US-20030100572-A1 | Novel pyridopyrimidones and uses thereof | ARIAD PHARMACEUTICALS,INC. | 2003-05-29 | — | — | US | disclosed |
| US-20030100573-A1 | Novel quinazolines and uses thereof | ARIAD PHARMACEUTICALS, INC. | 2003-05-29 | — | — | US | disclosed |
| WO-2003000270-A1 | NOVEL PYRIDOPYRIMIDONES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |
| WO-2003000186-A2 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | ARIAD PHARMACEUTICALS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105065-A1 | Novel quinolines and uses thereof | UQCRB, RECQL, QTRT2 | SMN1; SMN2 2348/4885LMNA 3055/4885GAA 2131/4885 |
| US-20040242611-A1 | NOVEL PHENYLAMINO-PYRIMIDINES AND USES THEREOF | DPYD, TYMP, DDX41 | SMN1; SMN2 3421/4885LMNA 3332/4885GAA 2812/4885 |
| US-20030100572-A1 | Novel pyridopyrimidones and uses thereof | UQCRB, RRM2B, CYP2B6 | SMN1; SMN2 1784/4885LMNA 2692/4885GAA 3534/4885 |
| US-20030105115-A1 | Novel pyridopyrimidines and uses thereof | DPYD, RRM2B, RRM2 | SMN1; SMN2 1945/4885LMNA 3430/4885GAA 3369/4885 |
| US-20030100573-A1 | Novel quinazolines and uses thereof | UQCRB, NQO2, RAB7A | SMN1; SMN2 2538/4885LMNA 3432/4885GAA 1768/4885 |
| US-20030114467-A1 | Novel pyrazolo- and pyrrolo-pyrimidines and uses thereof | TYMP, TYMS, DPYD | SMN1; SMN2 3296/4885LMNA 4118/4885GAA 3503/4885 |
| US-20030114486-A1 | Novel quinolinones and uses thereof | UGT2B7, RAB7A, UQCRB | SMN1; SMN2 3913/4885LMNA 1948/4885GAA 710/4885 |
| US-20040152671-A1 | Novel quinolines and uses thereof | UQCRB, RECQL, QTRT2 | SMN1; SMN2 2348/4885LMNA 3055/4885GAA 2131/4885 |
| US-20030130234-A1 | Novel indolinones and uses thereof | RDX, UQCRB, DRD1 | SMN1; SMN2 4278/4885LMNA 2594/4885GAA 3976/4885 |
| US-20040167101-A1 | Novel quinolinones and uses thereof | UGT2B7, RAB7A, UQCRB | SMN1; SMN2 3913/4885LMNA 1948/4885GAA 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.