Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5749526 | 0.81 | ADORA2A (0.43) | KDM4EADORA2AADORA1PDE4APDE4B | |
| SCHEMBL5754832 | 0.79 | CA1 (0.38) | KDM4ETRPV4ADORA2AADORA1PDE4A | |
| SCHEMBL5753766 | 0.73 | ALDH1A1 (0.42) | KDM4EMAPK1SMN1; SMN2BRD4CYP3A4 | |
| SCHEMBL24253799 | 0.72 | TRPV4 (0.52) | KDM4ETRPV4 | |
| SCHEMBL17992 | 0.71 | TRPV4 (0.42) | KDM4ETRPV4MAPK1SMN1; SMN2MAPT | |
| SCHEMBL6767370 | 0.70 | KDM4E (0.41) | KDM4EADORA2AADORA1MAPK1BRD4 | |
| SCHEMBL1728934 | 0.70 | KDM4E (0.40) | KDM4EADORA2AADORA1PDE4APDE4B | |
| SCHEMBL7015225 | 0.70 | BPTF (0.43) | KDM4EADORA2AADORA1PDE4APDE4B | |
| SCHEMBL5777794 | 0.68 | TRPV4 (0.39) | KDM4ETRPV4ADORA2AADORA1MAPK1 | |
| SCHEMBL2725966 | 0.68 | ALDH1A1 (0.44) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1387839-B1 | PROCESS FOR THE PRODUCTION OF QUINAZOLINES | PFIZER LTD (GB) | 2006-03-08 | — | — | EP | disclosed |
| US-20040158062-A1 | Process for the production of quinazolines | PFIZER INC | 2004-08-12 | — | — | US | disclosed |
| US-6734303-B2 | THERAPY FOR BENIGN PROSTATIC HYPERPLASIA | PFIZER INC. | 2004-05-11 | — | — | US | disclosed |
| EP-1387839-A1 | PROCESS FOR THE PRODUCTION OF QUINAZOLINES | Pfizer Limited (GB) | 2004-02-11 | — | — | EP | disclosed |
| US-20030004339-A1 | Process for the production of quinazolines | PFIZER INC. | 2003-01-02 | — | — | US | disclosed |
| WO-2002094815-A1 | PROCESS FOR THE PRODUCTION OF QUINAZOLINES | PFIZER LIMITED (GB) | 2002-11-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004339-A1 | Process for the production of quinazolines | BPHL, KLK3, AQP3 | KDM4E 2554/4885TRPV4 2627/4885ADORA2A 4608/4885 |
| US-20040158062-A1 | Process for the production of quinazolines | BPHL, QDPR, NQO2 | KDM4E 3087/4885TRPV4 2559/4885ADORA2A 4258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.