Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757754 | 0.90 | PTK2 (0.47) | PTK2ALKPRKD3LCKPRKCQ | |
| SCHEMBL5758741 | 0.85 | L3MBTL1 (0.52) | PTK2ALKLCKFLT1KDR | |
| SCHEMBL5759805 | 0.83 | CDK2 (0.41) | PTK2FGFR1FLT1KDRGSK3B | |
| SCHEMBL5758488 | 0.83 | ALK (0.73) | PTK2ALKPRKD3LCKPRKCQ | |
| SCHEMBL4244620 | 0.82 | PTK2 (0.52) | PTK2ALKPRKD3LCKPRKCQ | |
| SCHEMBL5760461 | 0.81 | ROCK1 (0.40) | PTK2AURKAJAK2KDRJAK3 | |
| SCHEMBL5759742 | 0.80 | SCN9A (0.42) | PTK2JAK2ABL1PDGFRBFGFR1 | |
| SCHEMBL5761986 | 0.80 | CDK4 (0.42) | AURKAJAK2KDRGSK3BJAK3 | |
| SCHEMBL4251626 | 0.80 | ALK (0.59) | PTK2ALKPRKD3LCKPRKCQ | |
| SCHEMBL4250254 | 0.80 | PTK2 (0.54) | PTK2ALKPRKD3LCKPRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242403-B1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | PFIZER PROD INC (US) | 2006-01-04 | — | — | EP | claimed |