Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | STAT5A | P42229 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5761986 | 0.86 | CDK4 (0.42) | SCN9ACDK2JAK2JAK3CDK4 | |
| SCHEMBL5760461 | 0.85 | ROCK1 (0.40) | CDK2JAK2JAK3EGFRROCK1 | |
| SCHEMBL5757754 | 0.84 | PTK2 (0.47) | CDK2JAK2JAK3CDK4PDGFRB | |
| SCHEMBL5757460 | 0.83 | ROCK1 (0.47) | SCN9ACDK2JAK2JAK3CDK4 | |
| SCHEMBL5758741 | 0.83 | L3MBTL1 (0.52) | CDK2SRCKDRFLT1FLT4 | |
| SCHEMBL5760336 | 0.82 | AURKA (0.45) | JAK2JAK3SYKFFAR1FFAR4 | |
| SCHEMBL5760444 | 0.81 | SYK (0.42) | JAK2JAK3EGFRROCK1FLT4 | |
| SCHEMBL5758924 | 0.81 | IDH1 (0.52) | SCN9AROCK1KDRFLT1FLT4 | |
| SCHEMBL5759805 | 0.80 | CDK2 (0.41) | CDK2CDK4EGFRFGFR1SRC | |
| SCHEMBL5760237 | 0.80 | PTK2 (0.58) | JAK2JAK3PDGFRBFGFR1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242403-B1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | PFIZER PROD INC (US) | 2006-01-04 | — | — | EP | claimed |