Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759742 | 0.86 | SCN9A (0.42) | CDK4CDK2GSK3BFFAR1FFAR4 | |
| SCHEMBL5760461 | 0.85 | ROCK1 (0.40) | CDK2AURKAKDRPIK3CAPIK3CB | |
| SCHEMBL5757754 | 0.84 | PTK2 (0.47) | CDK4CDK2GSK3BAURKAAURKB | |
| SCHEMBL5758741 | 0.83 | L3MBTL1 (0.52) | CDK2NPC1RAB9AAURKBKDR | |
| SCHEMBL5760681 | 0.82 | KDR (0.48) | CDK4CDK2GSK3BFFAR1FFAR4 | |
| SCHEMBL5760336 | 0.82 | AURKA (0.45) | FFAR1FFAR4AURKAAURKBJAK2 | |
| SCHEMBL5760444 | 0.81 | SYK (0.42) | AURKAJAK2JAK3 | |
| SCHEMBL5758924 | 0.81 | IDH1 (0.52) | SCN9AKDR | |
| SCHEMBL5759805 | 0.80 | CDK2 (0.41) | CDK4CDK2GSK3BNPC1KDR | |
| SCHEMBL5760237 | 0.80 | PTK2 (0.58) | GSK3BAURKAAURKBKDRJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242403-B1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | PFIZER PROD INC (US) | 2006-01-04 | — | — | EP | claimed |