Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.47 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758924 | 0.90 | IDH1 (0.52) | L3MBTL1KDRSYKFLT1FLT4 | |
| SCHEMBL5760461 | 0.88 | ROCK1 (0.40) | L3MBTL1KDRCDK5CDK5R1PTK2 | |
| SCHEMBL5757754 | 0.87 | PTK2 (0.47) | L3MBTL1KDRCDK5PTK2SYK | |
| SCHEMBL5759805 | 0.87 | CDK2 (0.41) | L3MBTL1KDRCDK5CDK5R1PTK2 | |
| SCHEMBL5760237 | 0.85 | PTK2 (0.58) | KDRCDK5PTK2SYKLCK | |
| SCHEMBL5761986 | 0.83 | CDK4 (0.42) | KDRNPC1RAB9AAURKBPIK3CA | |
| SCHEMBL5759742 | 0.83 | SCN9A (0.42) | KDRCDK5CDK5R1PTK2SYK | |
| SCHEMBL5758463 | 0.81 | KDR (0.55) | KDRCDK5CDK5R1PTK2MEN1 | |
| SCHEMBL5760262 | 0.80 | CYP1A2 (0.45) | KDRSRCCDK2 | |
| SCHEMBL5760336 | 0.79 | AURKA (0.45) | MEN1KMT2AMAPTSYKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242403-B1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | PFIZER PROD INC (US) | 2006-01-04 | — | — | EP | claimed |