Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760237 | 0.90 | PTK2 (0.58) | PTK2ALKGSK3BJAK2AURKA | |
| SCHEMBL5758741 | 0.87 | L3MBTL1 (0.52) | PTK2ALKCDK2AURKBKDR | |
| SCHEMBL5759805 | 0.85 | CDK2 (0.41) | PTK2GSK3BCDK4CDK2KDR | |
| SCHEMBL5761986 | 0.84 | CDK4 (0.42) | GSK3BCDK4CDK2BRD4JAK2 | |
| SCHEMBL5759742 | 0.84 | SCN9A (0.42) | PTK2GSK3BCDK4CDK2JAK2 | |
| SCHEMBL5760461 | 0.83 | ROCK1 (0.40) | PTK2CDK2JAK2AURKAKDR | |
| SCHEMBL5757748 | 0.83 | ALK (0.60) | PTK2ALKGSK3BCDK4CDK2 | |
| SCHEMBL5758924 | 0.82 | IDH1 (0.52) | KDRFLT1ROCK1SYKL3MBTL1 | |
| SCHEMBL5760336 | 0.80 | AURKA (0.45) | JAK2AURKAAURKBJAK3SYK | |
| SCHEMBL5760444 | 0.80 | SYK (0.42) | JAK2AURKAJAK3ROCK1SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242403-B1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | PFIZER PROD INC (US) | 2006-01-04 | — | — | EP | claimed |