Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758741 | 0.88 | L3MBTL1 (0.52) | PIK3CAPIK3CGFLT4KDRPIK3CB | |
| SCHEMBL5758924 | 0.86 | IDH1 (0.52) | ROCK1PLK4FLT4KDRL3MBTL1 | |
| SCHEMBL5761986 | 0.85 | CDK4 (0.42) | PIK3CAPIK3CGAURKAKDRPIK3CB | |
| SCHEMBL5759742 | 0.85 | SCN9A (0.42) | ROCK1FLT4KDREGFRJAK2 | |
| SCHEMBL5757754 | 0.83 | PTK2 (0.47) | ROCK1AURKAKDRL3MBTL1JAK2 | |
| SCHEMBL5759805 | 0.83 | CDK2 (0.41) | PIK3CAPIK3CGFLT4KDRPIK3CB | |
| SCHEMBL5760262 | 0.81 | CYP1A2 (0.45) | PLK4KDRJAK2JAK3CCNA2 | |
| SCHEMBL5760237 | 0.81 | PTK2 (0.58) | ROCK1AURKAKDRJAK2JAK3 | |
| SCHEMBL5760336 | 0.81 | AURKA (0.45) | AURKAJAK2JAK3 | |
| SCHEMBL5760158 | 0.80 | IGF1R (0.43) | ROCK1KDRALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242403-B1 | 2,4-DIAMINOPYRIMIDINE COMPOUNDS USFUL AS IMMUNOSUPPRESSANTS | PFIZER PROD INC (US) | 2006-01-04 | — | — | EP | claimed |