Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 4/20 | 0.53 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764239 | 0.84 | VNN1 (0.53) | VNN1HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL1753567 | 0.80 | PTGDR2 (0.67) | VNN1MAPT | |
| SCHEMBL3261173 | 0.73 | ALOX15 (0.56) | HDAC6HDAC1MEN1HPGDALOX15 | |
| SCHEMBL29383789 | 0.72 | BACE1 (0.62) | MEN1HPGDALOX15KMT2ALMNA | |
| SCHEMBL329155 | 0.72 | BACE1 (0.62) | MEN1HPGDALOX15KMT2ALMNA | |
| SCHEMBL2111844 | 0.72 | PDK1 (0.45) | MEN1KMT2ALMNANPSR1CYP3A4 | |
| SCHEMBL2113204 | 0.71 | ALDH1A1 (0.43) | CDK9MEN1HPGDALOX15KMT2A | |
| Phosphine SCHEMBL27555075 | 0.70 | BACE1 (0.60) | MEN1HPGDALOX15KMT2ALMNA | |
| Methane SCHEMBL27581120 | 0.70 | BACE1 (0.60) | MEN1HPGDALOX15KMT2ALMNA | |
| SCHEMBL2113926 | 0.70 | TRPM8 (0.39) | CDK9LMNANPSR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611091-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | claimed |
| WO-2004089885-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-10-21 | — | — | WO | claimed |