Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766908 | 1.00 | LMNA (0.38) | LMNAALDH1A1CYP3A4CYP2D6TSHR | |
| SCHEMBL5766806 | 0.89 | LMNA (0.37) | LMNAALDH1A1CYP3A4CYP2D6TSHR | |
| SCHEMBL5766815 | 0.89 | LMNA (0.37) | LMNAALDH1A1CYP3A4CYP2D6TSHR | |
| SCHEMBL4906739 | 0.88 | LMNA (0.37) | LMNAALDH1A1CYP3A4CYP2D6TSHR | |
| SCHEMBL4902859 | 0.88 | LMNA (0.37) | LMNAALDH1A1CYP3A4CYP2D6TSHR | |
| SCHEMBL5765990 | 0.85 | LMNA (0.38) | LMNAALDH1A1CYP3A4CYP2D6TSHR | |
| SCHEMBL4906723 | 0.85 | LMNA (0.38) | LMNAALDH1A1CYP3A4CYP2D6TSHR | |
| SCHEMBL4375219 | 0.82 | HTR1A (0.47) | LMNAALDH1A1CYP3A4CYP2D6TSHR | |
| SCHEMBL5103551 | 0.82 | LMNA (0.40) | LMNAALDH1A1CYP3A4CYP2D6TSHR | |
| SCHEMBL4368745 | 0.82 | LMNA (0.40) | LMNAALDH1A1CYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381614-B1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO¬2,3-f|QUINOXALINE | WYETH CORP (US) | 2006-08-02 | — | — | EP | disclosed |
| US-7008944-B2 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-Dioxino[2,3-f]quinoxaline | WYETH (US) | 2006-03-07 | — | — | US | disclosed |
| US-20040077652-A1 | Treating obsessive compulsive disorder, panic attacks, sexual disorders, eating disorders, obesity, drug abuse and ethanol or cocaine dependence; anxiolytic agents | WYETH | 2004-04-22 | — | — | US | disclosed |
| US-6617327-B2 | For therapy of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders | WYETH | 2003-09-09 | — | — | US | disclosed |
| US-20020183329-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoxaline | WYETH | 2002-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077652-A1 | Treating obsessive compulsive disorder, panic attacks, sexual disorders, eating disorders, obesity, drug abuse and ethanol or cocaine dependence; anxiolytic agents | OPRD1, DRD1, ADH1A | LMNA 4618/4885ALDH1A1 45/4885CYP3A4 688/4885 |
| US-20020183329-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinoxaline | OPRD1, OPRK1, DRD2 | LMNA 4332/4885ALDH1A1 185/4885CYP3A4 675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.