Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765093 | 0.91 | PTGDR2 (0.42) | MTNR1AMTNR1BKMT2AMAPTALDH1A1 | |
| SCHEMBL5762337 | 0.89 | MAPT (0.41) | PKMMAPTALDH1A1PLA2G2APOLB | |
| SCHEMBL5764801 | 0.86 | AURKA (0.42) | MAPTALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL5762171 | 0.86 | PLA2G1B (0.42) | PKMKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL5766775 | 0.85 | PLA2G2A (0.40) | PKMMTNR1AMTNR1BKMT2AMAPT | |
| SCHEMBL5764508 | 0.83 | PPARG (0.40) | PKMMTNR1AMTNR1BKMT2AMAPT | |
| SCHEMBL25136 | 0.76 | MTNR1B (0.60) | MTNR1AMTNR1BMAPTPLA2G2ANPC1 | |
| SCHEMBL5763739 | 0.75 | MEN1 (0.52) | KMT2AALDH1A1MEN1POLBNPC1 | |
| SCHEMBL5765021 | 0.75 | GAA (0.38) | KMT2AMAPTALDH1A1MEN1PLA2G2A | |
| SCHEMBL5762592 | 0.74 | PLA2G2A (0.57) | PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091738-B1 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| EP-1091738-A4 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6384041-B1 | ANTIINFLAMMATORY AGENT, TREATMENT OF SHOCK AND ENZYME INHIBITORS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |
| EP-1091738-A1 | BICYCLIC sPLA 2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000000201-A1 | BICYCLIC sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 2000-01-06 | — | — | WO | disclosed |