Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.42 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | CCNH | P51946 | 1/20 | 0.38 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762337 | 0.88 | MAPT (0.41) | AURKARPS6KB1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL5765082 | 0.86 | PKM (0.43) | SMN1; SMN2ALDH1A1MAPTLMNATSHR | |
| SCHEMBL5765093 | 0.86 | PTGDR2 (0.42) | SMN1; SMN2KDM4EALDH1A1MAPTHTT | |
| SCHEMBL5764673 | 0.85 | LMNA (0.37) | ABHD6SMN1; SMN2PTGER3MAPK1MAPT | |
| SCHEMBL5764869 | 0.79 | PLA2G2A (0.47) | AURKARPS6KB1RIPK1 | |
| SCHEMBL5762171 | 0.76 | PLA2G1B (0.42) | SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL5764178 | 0.73 | MAPT (0.40) | KDM4EALDH1A1MAPK1MAPTLMNA | |
| SCHEMBL5763931 | 0.70 | HSP90AA1 (0.40) | SMN1; SMN2PTGER3KDM4EALDH1A1PPARG | |
| SCHEMBL5763265 | 0.70 | PLA2G2A (0.52) | — | |
| SCHEMBL5763509 | 0.69 | PLA2G2A (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091738-B1 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6384041-B1 | ANTIINFLAMMATORY AGENT, TREATMENT OF SHOCK AND ENZYME INHIBITORS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |