Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765021 | 0.92 | GAA (0.38) | NPSR1POLBALDH1A1MAPTHPGD | |
| SCHEMBL5764178 | 0.90 | MAPT (0.40) | TSHRPOLBALDH1A1MAPTHSD17B10 | |
| SCHEMBL5764673 | 0.88 | LMNA (0.37) | PPARGTSHRPOLBMAPT | |
| SCHEMBL5764971 | 0.87 | PLA2G1B (0.40) | PPARGPOLBALDH1A1MAPTPLA2G2A | |
| SCHEMBL5766775 | 0.87 | PLA2G2A (0.40) | TSHRALDH1A1MAPTKMT2APLA2G2A | |
| SCHEMBL5763363 | 0.85 | ALOX5AP (0.42) | POLBALDH1A1MAPTSRCABL1 | |
| SCHEMBL5765082 | 0.83 | PKM (0.43) | TSHRPOLBALDH1A1MAPTKMT2A | |
| SCHEMBL5762802 | 0.77 | ALDH1A1 (0.47) | PPARGTSHRNPSR1POLBALDH1A1 | |
| SCHEMBL5766050 | 0.77 | PLA2G2A (0.53) | PLA2G2A | |
| SCHEMBL5765093 | 0.75 | PTGDR2 (0.42) | ALDH1A1MAPTHPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091738-B1 | BICYCLIC sPLA 2 INHIBITORS | LILLY CO ELI (US) | 2006-12-06 | — | — | EP | disclosed |
| US-6384041-B1 | ANTIINFLAMMATORY AGENT, TREATMENT OF SHOCK AND ENZYME INHIBITORS | ELI LILLY AND COMPANY | 2002-05-07 | — | — | US | disclosed |