Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL1782847 | 0.85 | HRH4 (0.36) | HRH1TDP1TSHR | |
| Benzophenone SCHEMBL3457993 | 0.85 | ALDH1A1 (0.42) | ALDH1A1HRH1KDM4EHTTSMN1; SMN2 | |
| Histamine SCHEMBL9363086 | 0.85 | HTR7 (0.42) | HMGB1KDM4ERAB9ATDP1KMT2A | |
| Histamine SCHEMBL28074178 | 0.83 | HRH1 (0.42) | HRH1SMN1; SMN2TDP1TSHRAPEX1 | |
| Histamine SCHEMBL4234179 | 0.83 | HRH4 (0.39) | HRH1SMN1; SMN2TDP1TSHRAPEX1 | |
| Histamine SCHEMBL8571326 | 0.83 | HRH1 (0.42) | ALDH1A1HRH1KDM4ESMN1; SMN2TDP1 | |
| Histamine SCHEMBL8789327 | 0.82 | HRH1 (0.37) | ALOX15HRH1KDM4ESMN1; SMN2TDP1 | |
| Histamine SCHEMBL8887482 | 0.82 | HRH4 (0.34) | HRH1TDP1TSHR | |
| Histamine SCHEMBL5840054 | 0.82 | HRH4 (0.38) | HRH1TDP1TSHR | |
| Histamine SCHEMBL11855302 | 0.81 | HRH1 (0.36) | ALDH1A1ALOX15HRH1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4740455-A | Heat developable light-sensitive material containing polymethine | FUJI PHOTO FILM CO., LTD. (JP) | 1988-04-26 | — | — | US | claimed |
| US-10545424-B2 | Liquid developer and method of producing liquid developer | CANON KABUSHIKI KAISHA (JP) | 2020-01-28 | — | — | US | disclosed |
| US-10290809-B2 | Macromolecular compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2019-05-14 | — | — | US | disclosed |
| US-20190094734-A1 | LIQUID DEVELOPER AND METHOD OF PRODUCING LIQUID DEVELOPER | CANON KABUSHIKI KAISHA (JP) | 2019-03-28 | — | — | US | disclosed |
| US-20160372675-A1 | MACROMOLECULAR COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-12-22 | — | — | US | disclosed |
| US-9472763-B2 | Macromolecular compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2016-10-18 | — | — | US | disclosed |
| US-9209404-B2 | Macromolecular compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-12-08 | — | — | US | disclosed |
| US-9006714-B2 | Photovoltaic device | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2015-04-14 | — | — | US | disclosed |
| US-8772763-B2 | Photovoltaic cell | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2014-07-08 | — | — | US | disclosed |
| US-20120217448-A1 | MACROMOLECULAR COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-08-30 | — | — | US | disclosed |
| US-4912027-A | A 1H-pyrazolo(5,1-C)-1,2,4-triazole magenta coupler | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1990-03-27 | — | — | US | disclosed |
| EP-0206461-B1 | SILVER HALIDE PHOTOGRAPHIC LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1989-12-13 | — | — | EP | disclosed |
| CN-1033053-A | 2-oxa--different cephalosporin compound, its manufacture method and contain the antimicrobial composition of this compound | OTSUKA PHARMA CO LTD (JP) | 1989-05-24 | — | — | CN | disclosed |
| US-H567-H | Silver halide color photographic light-sensitive materials containing cyan coupler and specific compound | FUJI PHOTO FILM CO., LTD. (JP) | 1989-01-03 | — | — | US | disclosed |
| US-4740455-A | Heat developable light-sensitive material containing polymethine | FUJI PHOTO FILM CO., LTD. (JP) | 1988-04-26 | — | — | US | disclosed |
| US-4740455-A | Heat developable light-sensitive material containing polymethine | FUJI PHOTO FILM CO., LTD. (JP) | 1988-04-26 | — | — | US | disclosed |
| EP-0137271-B1 | METHOD OF IMPROVING THE LIGHT RESISTANCE OF A DYE IMAGE | KONICA CORPORATION (JP) | 1987-11-04 | — | — | EP | disclosed |
| EP-0206461-A2 | Silver halide photographic light-sensitive material | KONICA CORPORATION (JP) | 1986-12-30 | — | — | EP | disclosed |
| US-4540653-A | METAL COMPLEX, ANILINO COUPLER | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1985-09-10 | — | — | US | disclosed |
| EP-0137271-A2 | Method of improving the light resistance of a dye image | KONICA CORPORATION (JP) | 1985-04-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10290809-B2 | Macromolecular compound | EXOSC4, TRPC6, MRPS22 | HRH1 3889/4885HMGB1 3189/4885ALDH1A1 3653/4885 |
| US-20160372675-A1 | MACROMOLECULAR COMPOUND | EXOSC4, TRPC6, MRPS22 | HRH1 3889/4885HMGB1 3189/4885ALDH1A1 3653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.