Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 6/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775281 | 0.87 | KDM4E (0.48) | ALDH1A1KDM4EMAPTGAAHSD17B10 | |
| SCHEMBL11152136 | 0.81 | MEN1 (0.46) | NR4A2ALDH1A1KDM4EMAPTPKM | |
| SCHEMBL5768460 | 0.80 | PFKFB1 (0.41) | NR4A2ALDH1A1KDM4EMAPTPKM | |
| SCHEMBL5392425 | 0.78 | ALDH1A1 (0.55) | NR4A2ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL5812465 | 0.74 | ALOX15 (0.54) | ALDH1A1KDM4EMAPTGAAHSD17B10 | |
| SCHEMBL29954956 | 0.73 | MEN1 (0.55) | ALDH1A1KDM4EMAPTGAAHSD17B10 | |
| SCHEMBL10941882 | 0.73 | MEN1 (0.55) | ALDH1A1KDM4EMAPTGAAHSD17B10 | |
| SCHEMBL29954951 | 0.73 | MEN1 (0.58) | ALDH1A1KDM4EMAPTPKMGAA | |
| SCHEMBL5769418 | 0.72 | NR4A2 (0.41) | NR4A2ALDH1A1KDM4EMAPTMEN1 | |
| SCHEMBL5399472 | 0.70 | ALDH1A1 (0.67) | ALDH1A1KDM4EMAPTGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472221-B1 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | GRUENENTHAL GMBH (DE) | 2006-03-22 | — | — | EP | disclosed |