Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.32 |
| ▸ | CDK9 | P50750 | 3/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769574 | 0.78 | PI4KB (0.36) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL5770367 | 0.77 | MAPK14 (0.41) | PI4KBMAPK14CYP3A4LMNACYP2C9 | |
| SCHEMBL5770827 | 0.75 | TP53 (0.48) | PI4KBMAPK14CYP3A4ALDH1A1LMNA | |
| SCHEMBL5773732 | 0.74 | KDM4E (0.38) | MAPK14CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL5767550 | 0.74 | MAPK14 (0.38) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL5774512 | 0.73 | ALDH1A1 (0.40) | PI4KBMAPK14KDM4EALDH1A1LMNA | |
| SCHEMBL5774648 | 0.73 | SYK (0.33) | PI4KBMAPK14CYP3A4 | |
| SCHEMBL5771480 | 0.73 | SSTR5 (0.47) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5773723 | 0.73 | MAPK14 (0.41) | MAPK14CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL5772303 | 0.73 | PDE4B (0.37) | PI4KBMAPK14CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664025-A1 | PYRROL DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | AstraZeneca AB (SE) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026149-A1 | PYRROL DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2005-03-24 | — | — | WO | disclosed |