Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 9/20 | 0.52 |
| ▸ | RXRB | P28702 | 9/20 | 0.52 |
| ▸ | RXRG | P48443 | 7/20 | 0.52 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774472 | 0.91 | RXRA (0.50) | ALDH1A1RXRARXRBRXRGNR4A2 | |
| SCHEMBL5774948 | 0.88 | FFAR1 (0.51) | ALDH1A1RXRARXRBRXRGNR4A2 | |
| SCHEMBL5776248 | 0.83 | TDO2 (0.45) | ALDH1A1RXRARXRBRXRGNR4A2 | |
| SCHEMBL5770831 | 0.82 | NR4A2 (0.52) | ALDH1A1RXRARXRBRXRGNR4A2 | |
| SCHEMBL5773828 | 0.81 | NR4A2 (0.47) | ALDH1A1RXRARXRBRXRGNR4A2 | |
| SCHEMBL5773427 | 0.80 | TDO2 (0.42) | ALDH1A1RXRARXRBRXRGEPHX2 | |
| SCHEMBL5773847 | 0.78 | CCNC (0.47) | ALDH1A1NR4A2SMN1; SMN2PTGS1KDM4E | |
| SCHEMBL5776861 | 0.78 | PPARA (0.48) | ALDH1A1RXRARXRBRXRGNR4A2 | |
| SCHEMBL5772923 | 0.78 | TSHR (0.55) | ALDH1A1RXRARXRBRXRGKDM4E | |
| SCHEMBL5772507 | 0.78 | RXRA (0.50) | ALDH1A1RXRARXRBRXRGNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | ALDH1A1 1045/4885RXRA 445/4885RXRB 494/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | ALDH1A1 682/4885RXRA 462/4885RXRB 550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.