Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777275 | 0.93 | LMNA (0.33) | TRPV1MAPTHDAC1HDAC6HPGD | |
| Trifluoroacetic Acid SCHEMBL5774050 | 0.90 | TRPV1 (0.43) | TRPV1MAPTHDAC1HDAC6FAAH | |
| Trifluoroacetic Acid SCHEMBL5777271 | 0.82 | GAA (0.37) | TRPV1MAPTHDAC6MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5772750 | 0.77 | MAPT (0.40) | TRPV1MAPTFAAHHPGDSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5776657 | 0.76 | MAPT (0.42) | TRPV1MAPTHDAC1HDAC6TP53 | |
| SCHEMBL5774056 | 0.76 | TRPV1 (0.38) | TRPV1HDAC1FAAHSPHK2HDAC2 | |
| Trifluoroacetic Acid SCHEMBL5774893 | 0.74 | GAA (0.47) | MAPTHDAC6TP53HDAC2MEN1 | |
| Trifluoroacetic Acid SCHEMBL5775717 | 0.73 | GSK3B (0.44) | TRPV1FAAHTP53MEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5775554 | 0.73 | HDAC4 (0.43) | TRPV1MAPTHDAC1HDAC6FAAH | |
| Trifluoroacetic Acid SCHEMBL5772663 | 0.71 | IDE (0.49) | HDAC6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | TRPV1 2864/4885MAPT 4701/4885HDAC1 353/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | TRPV1 3621/4885MAPT 4763/4885HDAC1 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.