Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099789 | 0.90 | HTR1D (0.47) | HTR1DHTR1AHTR1BKCNH2ALDH1A1 | |
| SCHEMBL5764977 | 0.89 | HTR1D (0.53) | HTR1DHTR1AHTR1BKCNH2ALDH1A1 | |
| SCHEMBL5771874 | 0.86 | KCNH2 (0.41) | KCNH2 | |
| SCHEMBL5750593 | 0.79 | HTR1D (0.46) | HTR1DHTR1AHTR1BKCNH2ALDH1A1 | |
| SCHEMBL5764950 | 0.76 | HTR1A (0.51) | HTR1DHTR1AHTR1BKCNH2 | |
| SCHEMBL5765233 | 0.75 | SLC2A1 (0.43) | HTR1DHTR1AKCNH2 | |
| SCHEMBL5765739 | 0.75 | ALDH1A1 (0.40) | HTR1DHTR1AHTR1BKCNH2ALDH1A1 | |
| SCHEMBL5751074 | 0.75 | NPC1 (0.41) | KCNH2ALDH1A1POLB | |
| SCHEMBL14573146 | 0.75 | KCNH2 (0.49) | HTR1DHTR1AHTR1BKCNH2 | |
| SCHEMBL5762645 | 0.74 | KCNH2 (0.53) | KCNH2ALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343780-B1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF BACTERIAL INFECTIONS | SMITHKLINE BEECHAM PLC (GB) | 2006-09-20 | — | — | EP | claimed |