Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.40 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP3 | P08254 | 2/20 | 0.40 |
| ▸ | MMP7 | P09237 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5663653 | 0.80 | MMP1 (0.55) | KDM4EADAMTS4MMP1MMP2MMP3 | |
| SCHEMBL5664360 | 0.80 | MMP1 (0.55) | KDM4EADAMTS4MMP1MMP2MMP3 | |
| Valine SCHEMBL9352525 | 0.74 | SLC1A3 (0.48) | KDM4EADAMTS4MMP1MMP2MMP9 | |
| Valine SCHEMBL9348623 | 0.74 | SLC1A3 (0.48) | KDM4EADAMTS4MMP1MMP2MMP9 | |
| Trifluoroacetic Acid SCHEMBL7394766 | 0.72 | NR3C1 (0.48) | KDM4EADAMTS4MMP1MMP2MMP9 | |
| Trifluoroacetic Acid SCHEMBL5663234 | 0.72 | NR3C1 (0.48) | KDM4EADAMTS4MMP1MMP2MMP9 | |
| SCHEMBL15448833 | 0.71 | ADAMTS4 (0.41) | KDM4EADAMTS4ALDH1A1ALOX5APFEN1 | |
| SCHEMBL8627896 | 0.70 | RAPGEF4 (0.38) | KDM4EMMP1MMP2MMP9MMP13 | |
| SCHEMBL20335011 | 0.70 | L3MBTL1 (0.58) | ADAMTS4MMP1MMP2MMP3MMP7 | |
| SCHEMBL20335013 | 0.70 | L3MBTL1 (0.58) | ADAMTS4MMP1MMP2MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944619-B1 | NOVEL INTEGRIN RECEPTOR ANTAGONISTS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2006-10-11 | — | — | EP | disclosed |
| US-6358976-B1 | FOR THERAPY AND PROPHYLAXIS OF CANCER METASTASIS, DIABETIC RETINOPATHY, NEOVASCULAR GLAUCOMA, THROMBOSIS, RESTENOSIS, OSTEOPOROSIS, OR MACULAR DEGENERATION | LANTHEUS MI REAL ESTATE, LLC | 2002-03-19 | — | — | US | disclosed |
| US-6130231-A | SUBSTITUTED 2,3-DIHYDROQUINOLIN-4-ONES | DUPONT PHARMACEUTICALS (US) | 2000-10-10 | — | — | US | disclosed |