Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774466 | 0.80 | ALOX15 (0.46) | ALOX15GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL5397710 | 0.79 | ALOX15 (0.55) | POLBKDM4EMAPTSMN1; SMN2GPR17 | |
| SCHEMBL5775281 | 0.77 | KDM4E (0.48) | KDM4EMAPTSMN1; SMN2ALOX15KMT2A | |
| SCHEMBL5776615 | 0.74 | KDM4E (0.45) | KDM4EMAPTSMN1; SMN2ALOX15KMT2A | |
| SCHEMBL5812465 | 0.72 | ALOX15 (0.54) | KDM4EMAPTSMN1; SMN2ALOX15USP2 | |
| SCHEMBL29955981 | 0.71 | MAPT (0.49) | POLBKDM4EMAPTSMN1; SMN2ERN1 | |
| SCHEMBL6892583 | 0.67 | ALDH1A1 (0.46) | KDM4EMAPTSMN1; SMN2CYP3A4L3MBTL1 | |
| SCHEMBL7211988 | 0.67 | ALDH1A1 (0.54) | POLBKDM4EMAPTSMN1; SMN2ALOX15 | |
| SCHEMBL8794649 | 0.66 | ALOX15 (0.47) | POLBKDM4EMAPTSMN1; SMN2GPR17 | |
| SCHEMBL5956567 | 0.65 | KDM4E (0.69) | POLBKDM4EMAPTSMN1; SMN2GPR17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472221-B1 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | GRUENENTHAL GMBH (DE) | 2006-03-22 | — | — | EP | disclosed |
| EP-1472221-A2 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | Grünenthal GmbH (DE) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003037863-A2 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | Grünenthal GmbH (DE) | 2003-05-08 | — | — | WO | disclosed |