Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | EEF2K | O00418 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776630 | 0.92 | MAOB (0.40) | MAOBHDAC1FFAR1FFAR4PIM1 | |
| SCHEMBL5774651 | 0.89 | MAOB (0.37) | MAOBHDAC1KDRTRPM4VCP | |
| SCHEMBL5775682 | 0.88 | MGLL (0.41) | MAOBHDAC1FFAR1FFAR4HDAC3 | |
| SCHEMBL6162028 | 0.81 | PTPN1 (0.42) | MAOBKDRTRPM4VCPFFAR1 | |
| SCHEMBL5777269 | 0.80 | MAOB (0.41) | MAOBHDAC1FFAR1FFAR4PIM1 | |
| SCHEMBL5774430 | 0.77 | MAOB (0.40) | MAOBFFAR1FFAR4L3MBTL1 | |
| SCHEMBL5775678 | 0.76 | MGLL (0.43) | MAOBHDAC1FFAR1FFAR4PIM1 | |
| SCHEMBL6166287 | 0.75 | ACMSD (0.38) | MAOBTRPM4FFAR1FFAR4CYP1A2 | |
| SCHEMBL5779454 | 0.75 | ROCK2 (0.45) | MAOBHDAC1HDAC2POLB | |
| SCHEMBL6164962 | 0.75 | MAOB (0.43) | MAOBFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368345-B1 | ALKOXYCARBONYLAMINO HETEROARYL CARBOXYLIC ACID DERIVATIVES AS IP ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2006-03-22 | — | — | EP | claimed |