SCHEMBL577886

SCHEMBL577886

COc1ccsc1B(O)O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.44
ENPP2 Q13822 3/20 0.43
ORAI1 Q96D31 1/20 0.38
ORAI2 Q96SN7 1/20 0.38
ORAI3 Q9BRQ5 1/20 0.38
CA1 P00915 3/20 0.35
CA2 P00918 3/20 0.35
KMT2A Q03164 3/20 0.33
CA12 O43570 1/20 0.33
CA4 P22748 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
SMPD3 Q9NY59 1/20 0.33
TSHR P16473 2/20 0.33
MAPT P10636 2/20 0.33
GAA P10253 1/20 0.33
TP53 P04637 2/20 0.32
TUBB4A P04350 3/20 0.32
TUBB P07437 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1243242 0.77 IKBKB (0.35) KEAP1KMT2AMAPTMEN1CYP1A2
SCHEMBL14690901 0.74 KEAP1 (0.34) KEAP1ENPP2
SCHEMBL868397 0.72 MAPT (0.35) ENPP2MAPT
SCHEMBL5154547 0.70
SCHEMBL133332 0.70
SCHEMBL5133848 0.69 KEAP1 (0.52) KEAP1CA1CA2KMT2ACA12
SCHEMBL10509635 0.68
SCHEMBL14645263 0.68 KMT2A (0.49) KMT2ATSHRMEN1KDM4EALDH1A1
SCHEMBL2183638 0.67
SCHEMBL2686757 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106636043-B Method for producing protease 广州立白企业集团有限公司 2020-04-07 CN claimed
EP-4697957-A1 COMPOSITION COMPRISING AN ANTIMICROBIAL AGENT AND AN ALKOXYLATED AMINE BASF SE (DE) 2026-02-25 EP disclosed
US-12522813-B2 Mannanase for formulations having pH 5-12 BASF SE (DE) 2026-01-13 US disclosed
US-20250234861-A1 LACTONES FOR ENHANCING THE ACTIVITY OF ANTIMICROBIAL AGENTS BASF SE (DE) 2025-07-24 US disclosed
US-20250040539-A1 COMPOSITION COMPRISING AN ANTIMICROBIAL AGENT AND A CARBOXAMIDE BASF SE (DE) 2025-02-06 US disclosed
WO-2024218124-A1 COMPOSITION COMPRISING AN ANTIMICROBIAL AGENT AND AN ALKOXYLATED AMINE BASF SE (DE) 2024-10-24 WO disclosed
EP-4447676-A1 LACTONES FOR ENHANCING THE ACTIVITY OF ANTIMICROBIAL AGENTS BASF SE (DE) 2024-10-23 EP disclosed
EP-4447675-A1 COMPOSITION COMPRISING AN ANTIMICROBIAL AGENT AND A CARBOXAMIDE BASF SE (DE) 2024-10-23 EP disclosed
US-20240279627-A1 COMPOSITIONS COMPRISING A LIPOLYTIC ENZYME VARIANT AND METHODS OF USE THEREOF DANISCO US INC (US) 2024-08-22 US disclosed
CN-118401108-A Lactones for enhancing the activity of antimicrobial agents 巴斯夫欧洲公司 2024-07-26 CN disclosed
US-7884107-B2 Human Double Minute 2 (HDM2) protein inhibitors; anticancer agents MERCK (US) 2011-02-08 US disclosed
US-7884107-B2 Human Double Minute 2 (HDM2) protein inhibitors; anticancer agents MERCK (US) 2011-02-08 US disclosed
US-7884107-B2 Human Double Minute 2 (HDM2) protein inhibitors; anticancer agents MERCK (US) 2011-02-08 US disclosed
WO-2010118078-A1 MACROCYCLIC SERINE PROTEASE INHIBITORS IDENIX PHARMACEUTICALS, INC. (US) 2010-10-14 WO disclosed
US-20100260710-A1 MACROCYCLIC SERINE PROTEASE INHIBITORS IDENIX PHARMACEUTICALS, INC. (US) 2010-10-14 US disclosed
EP-2035416-A1 SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF SCHERING CORPORATION (US) 2009-03-18 EP disclosed
WO-2008005268-A1 SUBSTITUTED PIPERIDINES THAT INCREASE P53 ACTIVITY AND THE USES THEREOF SCHERING CORPORATION (US) 2008-01-10 WO disclosed
US-20080004287-A1 Substituted Piperidines that Increase P53 Activity and the Uses Thereof SCHERING CORPORATION 2008-01-03 US disclosed
US-20080004287-A1 Substituted Piperidines that Increase P53 Activity and the Uses Thereof SCHERING CORPORATION 2008-01-03 US disclosed
US-20080004287-A1 Substituted Piperidines that Increase P53 Activity and the Uses Thereof SCHERING CORPORATION 2008-01-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250234861-A1 LACTONES FOR ENHANCING THE ACTIVITY OF ANTIMICROBIAL AGENTS CYP51A1, LSS, OLA1 KEAP1 1153/4885ENPP2 2006/4885ORAI1 1156/4885
US-20080004287-A1 Substituted Piperidines that Increase P53 Activity and the Uses Thereof TP53, MDM2, TP53BP1 KEAP1 294/4885ENPP2 3182/4885ORAI1 2380/4885
US-20250040539-A1 COMPOSITION COMPRISING AN ANTIMICROBIAL AGENT AND A CARBOXAMIDE PDF, AADAC, NAAA KEAP1 2696/4885ENPP2 757/4885ORAI1 2776/4885
US-20100260710-A1 MACROCYCLIC SERINE PROTEASE INHIBITORS SERPINB1, SPINT2, PRSS1 KEAP1 517/4885ENPP2 1096/4885ORAI1 4590/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.