SCHEMBL577897

SCHEMBL577897

[C]1c2ccccc2Oc2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 2/20 0.42
MAOB P27338 2/20 0.42
ALOX5 P09917 1/20 0.42
AHR P35869 3/20 0.37
ABCG2 Q9UNQ0 1/20 0.35
ITGB2 P05107 1/20 0.35
ICAM1 P05362 1/20 0.35
ITGAL P20701 1/20 0.35
ATM Q13315 2/20 0.34
KDM4E B2RXH2 2/20 0.34
TRPA1 O75762 1/20 0.34
MAPK1 P28482 1/20 0.34
GAA P10253 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
P2RX4 Q99571 1/20 0.32
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL526503 0.79 ALOX15 (0.35) MAOAMAOBALOX5AHR
Arsenic SCHEMBL28557236 0.77
SCHEMBL3102452 0.73 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL29383458 0.73 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL4571011 0.73 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL8668546 0.73 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL205284 0.73
SCHEMBL8776016 0.73 CYP2A6 (0.36) KDM4EALDH1A1MAPTLMNASMN1; SMN2
SCHEMBL125113 0.73 MAOA (0.56) MAOAMAOBALOX5AHRABCG2
SCHEMBL29724179 0.73 MAOA (0.56) MAOAMAOBALOX5AHRABCG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024143358-A1 RECYCLED POLYCARBONATE RESIN AND METHOD FOR PRODUCING SAME 三菱ケミカル株式会社 2024-07-04 WO claimed
EP-4380998-A2 METHOD OF SYNTHESIZING A MUCIN AND PRODUCT THEREOF Research Foundation Of The City University Of New York (US) 2024-06-12 EP claimed
US-20240182950-A1 METHODS AND SYSTEMS FOR CHARACTERIZING PHOSPHOSERINE-CONTAINING POLYPEPTIDES Quantum-Si Incorporated (US) 2024-06-06 US claimed
WO-2024086781-A2 METHODS AND SYSTEMS FOR CHARACTERIZING PHOSPHOSERINE-CONTAINING POLYPEPTIDES Quantum-Si Incorporated (US) 2024-04-25 WO claimed
WO-2023210563-A1 COMPOSITION CONTAINING BISPHENOL, PRODUCTION METHOD FOR SAME, PRODUCTION METHOD FOR BISPHENOL A, AND PRODUCTION METHOD FOR POLYCARBONATE RESIN 三菱ケミカル株式会社 2023-11-02 WO claimed
WO-2023014875-A2 METHOD OF SYNTHESIZING A MUCIN AND PRODUCT THEREOF RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) 2023-02-09 WO claimed
EP-3262058-A1 A COMPOUND FOR PREPARING POLYPEPTIDES Universität Wien (AT) 2018-01-03 EP claimed
WO-2016135071-A1 A COMPOUND FOR PREPARING POLYPEPTIDES Universität Wien (AT) 2016-09-01 WO claimed
US-20140171455-A1 Reduction of Microglia-Mediated Neurotoxicity by Kv1.3 Inhibition THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2014-06-19 US claimed
EP-2717871-A2 REDUCTION OF MICROGLIA-MEDIATED NEUROTOXICITY BY KV1.3 INHIBITION The Regents of the University of California (US) 2014-04-16 EP claimed
WO-2006048225-A1 QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARINIC M3 RECEPTOR ANTAGONISTS NOVARTIS AG (CH) 2006-05-11 WO claimed
EP-1569899-A2 SUBSTITUTED 3-ALKYL AND 3-ARYLALKYL i 1H /i -INDOL-1-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) Wyeth (US) 2005-09-07 EP claimed
WO-2004052853-A2 SUBSTITUTED 3-ALKYL AND 3-ARYLALKYL 1H-INDOL-1-YL ACETIC ACID DERIVATIVES AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) WYETH (US) 2004-06-24 WO claimed
US-20040116488-A1 Substituted 3-alkyl and 3-arylalkyl 1H-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) WYETH 2004-06-17 US claimed
US-5707559-A PROVIDING A STABLE 1,2-DIOXETANE WHICH FORMS INTERMEDIATE UNSTABLE COMPOUNDS WHEN TRIGGERED TO REMOVE BLOCKING GROUPS BY ACTIVATING AGENT SO THAT UNSTABLE COMPOUND DECOMPOSES TO FORM LIGHT AND TWO CARBONYL COMPOUNDS TROPIX, INC. (US) 1998-01-13 US claimed
US-5332857-A 3,5-dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents PFIZER INC. (US) 1994-07-26 US claimed
EP-0312269-B1 3,5-DIHYDROXY-6,8-NONADIENOIC ACIDS AND DERIVATIVES AS HYPOCHOLESTEROLEMIC AGENTS PFIZER INC. (US) 1993-06-16 EP claimed
US-4877779-A CALCIUM CHANNEL BLOCKERS; TREATMENT OF IRRITABLE BOWEL SYNDROME MARION LABORATORIES, INC. (US) 1989-10-31 US claimed
WO-1989003212-A1 3,5-DIHYDROXY-6,8-NONADIENOIC ACIDS AND DERIVATIVES AS HYPOCHOLESTEROLEMIC AGENTS PFIZER INC. (US) 1989-04-20 WO claimed
EP-0312269-A2 3,5-Dihydroxy-6,8-nonadienoic acids and derivatives as hypocholesterolemic agents PFIZER INC. (US) 1989-04-19 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140171455-A1 Reduction of Microglia-Mediated Neurotoxicity by Kv1.3 Inhibition KCNMA1, KCNN1, KCNN3 MAOA 657/4885MAOB 1516/4885ALOX5 2002/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.