Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780537 | 0.92 | P2RX7 (0.40) | GNRHRKCNH2SMYD3TSHRDPP4 | |
| SCHEMBL5782306 | 0.83 | HTR2A (0.40) | GNRHRKCNH2SMYD3HTTLMNA | |
| SCHEMBL5600002 | 0.75 | P2RX7 (0.37) | GNRHRKCNH2HTR2AHTR2CDPP4 | |
| SCHEMBL5780422 | 0.75 | P2RX7 (0.36) | GNRHRKCNH2DPP4HCRTR1HCRTR2 | |
| SCHEMBL5598980 | 0.75 | LMNA (0.38) | GNRHRKCNH2SMYD3HTTLMNA | |
| SCHEMBL5599096 | 0.75 | GNRHR (0.41) | GNRHRKCNH2SMYD3HSD11B1PDK1 | |
| SCHEMBL5783811 | 0.74 | HTT (0.36) | SMYD3HTTLMNATSHRKDM4E | |
| SCHEMBL5599358 | 0.74 | PARP1 (0.36) | GNRHRKCNH2DPP4PDK1PDK2 | |
| SCHEMBL5783985 | 0.74 | DPP4 (0.34) | GNRHRKCNH2HTR2AHTR2CDPP4 | |
| SCHEMBL5782925 | 0.74 | LMNA (0.39) | HTTLMNAMAPTKDM4EHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |